Non-pharmacological therapeutic paradigms in stress-induced depression: from novel therapeutic perspective with focus on cell-based strategies.

IF 2.6 4区 医学 Q3 NEUROSCIENCES
Maryam Azarfarin, Mahdi Mohammadzadeh Shahla, Gisou Mohaddes, Masoomeh Dadkhah
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Abstract

Major depressive disorder (MDD) is considered a psychiatric disorder and have a relationship with stressful events. Although the common therapeutic approaches against MDD are diverse, a large number of patients do not present an adequate response to antidepressant treatments. On the other hand, effective non-pharmacological treatments for MDD and their tolerability are addressed. Several affective treatments for MDD are used but non-pharmacological strategies for decreasing the common depression-related drugs side effects have been focused recently. However, the potential of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs), microRNAs (miRNAs) as cell-based therapeutic paradigms, besides other non-pharmacological strategies including mitochondrial transfer, plasma, transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and exercise therapy needs to further study. This review explores the therapeutic potential of cell-based therapeutic non-pharmacological paradigms for MDD treatment. In addition, plasma therapy, mitotherapy, and exercise therapy in several in vitro and in vivo conditions in experimental disease models along with tDCS and TMS will be discussed as novel non-pharmacological promising therapeutic approaches.

应激性抑郁症的非药物治疗范式:以细胞为基础的新治疗视角。
重度抑郁症(MDD)被认为是一种精神疾病,与压力事件有关。尽管针对重度抑郁症的常见治疗方法多种多样,但大量患者对抗抑郁治疗没有充分的反应。另一方面,对重度抑郁症的有效的非药物治疗及其耐受性进行了讨论。目前已使用了几种情感治疗重度抑郁症的方法,但减少常见抑郁相关药物副作用的非药物治疗策略最近受到关注。然而,除了线粒体转移、血浆、经颅直流电刺激(tDCS)、经颅磁刺激(TMS)和运动治疗等非药物治疗策略外,来自间充质干细胞(MSCs)的细胞外囊泡(ev)、microRNAs (miRNAs)作为细胞治疗范例的潜力还需要进一步研究。本文综述了以细胞为基础的非药物治疗模式对重度抑郁症的治疗潜力。此外,血浆治疗、线粒体治疗和运动治疗在实验疾病模型的几种体外和体内条件下,以及tDCS和TMS将作为新的非药物治疗方法进行讨论。
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY
自引率
5.30%
发文量
30
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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