{"title":"Improving the outcome in leukemia patients by controlling subthreshold depression and cancer-related fatigue.","authors":"Fa-Yang Xiang, Xin-Ke Li","doi":"10.5498/wjp.v15.i2.99299","DOIUrl":null,"url":null,"abstract":"<p><p>Patients with leukemia often suffer from the combined effects of cancer-related fatigue (CRF) and subthreshold depression, which mutually exacerbate each other in a vicious cycle. In this editorial, we comment on the article by Liu <i>et al</i>, published in the <i>World Journal of Psychiatry</i>. We further elucidate the profound impact of subthreshold depressive symptoms on the experience of CRF and complications in patients with leukemia. This editorial highlights the importance of early identification and treatment of subclinical depression, and advocates for a multidisciplinary and integrated treatment approach that includes social support, psychological interventions, and individualized treatment plans. Future research needs to explore the biological mechanisms underlying the interaction between the two to develop more effective prevention and treatment strategies.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"99299"},"PeriodicalIF":3.9000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758043/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5498/wjp.v15.i2.99299","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
Abstract
Patients with leukemia often suffer from the combined effects of cancer-related fatigue (CRF) and subthreshold depression, which mutually exacerbate each other in a vicious cycle. In this editorial, we comment on the article by Liu et al, published in the World Journal of Psychiatry. We further elucidate the profound impact of subthreshold depressive symptoms on the experience of CRF and complications in patients with leukemia. This editorial highlights the importance of early identification and treatment of subclinical depression, and advocates for a multidisciplinary and integrated treatment approach that includes social support, psychological interventions, and individualized treatment plans. Future research needs to explore the biological mechanisms underlying the interaction between the two to develop more effective prevention and treatment strategies.
期刊介绍：
The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.
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