Effects of Pattern-Reversal Visual Stimulation on Brain Activity in Migraineurs and General Population.

IF 1.9 4区 医学 Q4 NEUROSCIENCES
Lívia Shirahige, Fernanda Nogueira, Lorena Melo, Ruxandra Ungureanu, Sérgio Rocha, Rodrigo Brito, Thyciane Mendonça, Abelardo de Farias, Maria das Graças Rodrigues de Araújo, Daniele Piscitelli, Kátia Monte-Silva
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Abstract

Background: A better understanding of migraine pathophysiology through standardized methods could facilitate the development of more effective therapeutic approaches for migraine sufferers. However, neurophysiological studies with migraine sufferers present larger variability, as most contain only a single measurement.

Objective: This observational study aimed to compare the cortical and visual excitability of migraine sufferers, individuals with other types of headaches, and healthy participants in response to pattern-reversal visual stimulation.

Methods: Fifty-nine individuals were classified by a neurologist into the following groups: (i) migraineurs (n = 25); (ii) other types of headaches (n = 23); (iii) healthy (n = 11). Habituation during pattern-reversal visual stimulation was assessed by visual evoked potentials. Visual and motor cortex excitability were evaluated before and after pattern-reversal visual stimulation.

Results: We found no intergroup differences in motor and visual excitability measures after pattern-reversal visual stimulation. Compared to the healthy group, migraineurs and individuals with other types of headaches displayed a reduction in phosphene threshold after pattern-reversal visual stimulation. Additionally, an increase in visual cortical excitability in these groups was also observed. Lastly, the habituation in individuals with migraines and other types of headaches was lower compared to healthy individuals. Therefore, the lack of habituation may not be exclusively associated with the pathophysiological mechanisms of migraine.

Conclusion: Individuals who experience headaches, including migraineurs, have an increased visual cortical excitability in response to visual stimuli. This finding is promising for guiding future neurophysiological research to identify cortical biomarkers in migraineurs and in other types of headaches.

模式反转视觉刺激对偏头痛患者和一般人群脑活动的影响。
背景:通过标准化的方法更好地了解偏头痛的病理生理可以促进偏头痛患者更有效的治疗方法的发展。然而,针对偏头痛患者的神经生理学研究显示出更大的可变性,因为大多数研究只包含单一的测量结果。目的:本观察性研究旨在比较偏头痛患者、其他类型头痛患者和健康受试者对模式逆转视觉刺激的皮层和视觉兴奋性。方法:59例患者由神经科医生分为以下组:(i)偏头痛患者(n = 25);(ii)其他类型头痛(n = 23);(iii)健康(n = 11)。通过视觉诱发电位评估模式反转视觉刺激过程中的习惯化。在模式反转视觉刺激前后评估视觉和运动皮层的兴奋性。结果:我们发现在模式反转视觉刺激后,运动和视觉兴奋性测量在组间没有差异。与健康组相比,偏头痛患者和患有其他类型头痛的个体在模式逆转视觉刺激后显示出磷幻视阈值的降低。此外,还观察到这些组的视觉皮层兴奋性增加。最后,与健康人群相比,偏头痛和其他类型头痛患者的习惯化程度较低。因此,缺乏习惯化可能并不完全与偏头痛的病理生理机制有关。结论:经历头痛的个体,包括偏头痛患者,对视觉刺激的视觉皮层兴奋性增加。这一发现有望指导未来的神经生理学研究,以识别偏头痛和其他类型头痛的皮质生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.40
自引率
3.60%
发文量
22
审稿时长
>12 weeks
期刊介绍: This interdisciplinary journal publishes papers relating to the plasticity and response of the nervous system to accidental or experimental injuries and their interventions, transplantation, neurodegenerative disorders and experimental strategies to improve regeneration or functional recovery and rehabilitation. Experimental and clinical research papers adopting fresh conceptual approaches are encouraged. The overriding criteria for publication are novelty, significant experimental or clinical relevance and interest to a multidisciplinary audience. Experiments on un-anesthetized animals should conform with the standards for the use of laboratory animals as established by the Institute of Laboratory Animal Resources, US National Academy of Sciences. Experiments in which paralytic agents are used must be justified. Patient identity should be concealed. All manuscripts are sent out for blind peer review to editorial board members or outside reviewers. Restorative Neurology and Neuroscience is a member of Neuroscience Peer Review Consortium.
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