Dynamic and static brain functional abnormalities in autism patients at different developmental stages.

IF 1.6 4区医学 Q4 NEUROSCIENCES

Neuroreport Pub Date : 2025-03-05 Epub Date: 2025-02-12 DOI:10.1097/WNR.0000000000002139

Haonan Li, Mingxing Han, Shaoting Tang, Yaqian Yang

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引用次数: 0

Abstract

To date, most studies on autism spectrum disorder (ASD) have focused on specific age ranges, while the mechanisms underlying the entire developmental process of autism patients remain unclear. The aim of this study was to investigate the alterations in brain function in autistic individuals at different developmental stages by resting-state functional MRI (rs-fMRI). We obtained rs-fMRI data from 173 ASD and 178 typical development (TD) individuals in Autism Brain Imaging Data Exchange, spanning child, adolescent, and adult groups. We characterized local brain activity using the amplitude of low-frequency fluctuations (ALFFs), regional homogeneity (ReHo), dynamic ALFF (dALFF), and dynamic ReHo (dReHo) metrics. Pearson correlation analyses were conducted on relationships between Autism Diagnostic Observation Schedule scores and activity measures in abnormal brain regions. We found abnormal ALFF values in the medial and lateral orbitofrontal gyrus and right insula cortex with ASD compared with the TD group. In addition, compared with adolescents with ASD, we found that adults with ASD exhibited an increase in dReHo values in the posterior lateral frontal lobe. We also found that changes in ALFF were associated with the severity of autism. We found abnormal activity in multiple brain regions in individuals with autism and correlated it with clinical characteristics. Our results may provide some help for further exploring the age-related neurobiological mechanisms of ASD patients.

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来源期刊

Neuroreport 医学-神经科学

CiteScore

3.20

自引率

0.00%

发文量

150

审稿时长

1 months

期刊介绍： NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.