Dynamic and static brain functional abnormalities in autism patients at different developmental stages.

IF 1.6 4区医学 Q4 NEUROSCIENCES

Neuroreport Pub Date : 2025-03-05 Epub Date: 2025-02-12 DOI:10.1097/WNR.0000000000002139

Haonan Li, Mingxing Han, Shaoting Tang, Yaqian Yang

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引用次数: 0

Abstract

To date, most studies on autism spectrum disorder (ASD) have focused on specific age ranges, while the mechanisms underlying the entire developmental process of autism patients remain unclear. The aim of this study was to investigate the alterations in brain function in autistic individuals at different developmental stages by resting-state functional MRI (rs-fMRI). We obtained rs-fMRI data from 173 ASD and 178 typical development (TD) individuals in Autism Brain Imaging Data Exchange, spanning child, adolescent, and adult groups. We characterized local brain activity using the amplitude of low-frequency fluctuations (ALFFs), regional homogeneity (ReHo), dynamic ALFF (dALFF), and dynamic ReHo (dReHo) metrics. Pearson correlation analyses were conducted on relationships between Autism Diagnostic Observation Schedule scores and activity measures in abnormal brain regions. We found abnormal ALFF values in the medial and lateral orbitofrontal gyrus and right insula cortex with ASD compared with the TD group. In addition, compared with adolescents with ASD, we found that adults with ASD exhibited an increase in dReHo values in the posterior lateral frontal lobe. We also found that changes in ALFF were associated with the severity of autism. We found abnormal activity in multiple brain regions in individuals with autism and correlated it with clinical characteristics. Our results may provide some help for further exploring the age-related neurobiological mechanisms of ASD patients.

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不同发育阶段自闭症患者动态和静态脑功能异常。

迄今为止，大多数关于自闭症谱系障碍（ASD）的研究都集中在特定的年龄范围，而自闭症患者整个发育过程的潜在机制尚不清楚。本研究旨在利用静息状态功能磁共振成像（rs-fMRI）研究不同发育阶段自闭症患者脑功能的变化。我们在自闭症脑成像数据交换中获得了173名ASD和178名典型发育（TD）个体的rs-fMRI数据，涵盖儿童、青少年和成人群体。我们使用低频波动幅度（ALFFs）、区域均匀性（ReHo）、动态ALFF （dALFF）和动态ReHo （dReHo）指标来表征局部大脑活动。对自闭症诊断观察量表得分与异常脑区活动量的关系进行Pearson相关分析。我们发现，与TD组相比，ASD患者的眶额回内侧、外侧和右岛叶皮层的ALFF值异常。此外，与青少年ASD患者相比，我们发现成人ASD患者后外侧额叶dReHo值增加。我们还发现ALFF的变化与自闭症的严重程度有关。我们发现自闭症患者的多个大脑区域存在异常活动，并将其与临床特征联系起来。我们的研究结果可能为进一步探索ASD患者年龄相关的神经生物学机制提供一些帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroreport 医学-神经科学

CiteScore

3.20

自引率

0.00%

发文量

150

审稿时长

1 months

期刊介绍： NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.