Embracing Internal States: A Review of Optimization of Repetitive Transcranial Magnetic Stimulation for Treating Depression.

IF 5.9 2区医学 Q1 NEUROSCIENCES

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-20 DOI:10.1007/s12264-024-01347-3

Tingting Wu, Qiuxuan Yu, Ximei Zhu, Yinjiao Li, Mingyue Zhang, Jiahui Deng, Lin Lu

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引用次数: 0

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a rapid and effective therapy for major depressive disorder; however, there is significant variability in therapeutic outcomes both within and across individuals, with approximately 50% of patients showing no response to rTMS treatment. Many studies have personalized the stimulation parameters of rTMS (e.g., location and intensity of stimulation) according to the anatomical and functional structure of the brain. In addition to these parameters, the internal states of the individual, such as circadian rhythm, behavior/cognition, neural oscillation, and neuroplasticity, also contribute to the variation in rTMS effects. In this review, we summarize the current literature on the interaction between rTMS and internal states. We propose two possible methods, multimodal treatment, and adaptive closed-loop treatment, to integrate patients' internal states to achieve better rTMS treatment for depression.

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拥抱内在状态：重复经颅磁刺激治疗抑郁症的优化研究综述。

重复经颅磁刺激（rTMS）是一种快速有效的治疗重度抑郁症的方法。然而，个体内部和个体之间的治疗结果存在显著差异，大约50%的患者对rTMS治疗无反应。许多研究根据大脑的解剖结构和功能结构对rTMS的刺激参数（如刺激的位置和强度）进行了个性化设计。除了这些参数外，个体的内部状态，如昼夜节律、行为/认知、神经振荡和神经可塑性，也有助于rTMS效应的变化。本文对rTMS与内部状态相互作用的研究进展进行了综述。我们提出两种可能的方法，多模式治疗和自适应闭环治疗，以整合患者的内部状态，以实现更好的rTMS治疗抑郁症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience bulletin NEUROSCIENCES-

CiteScore

7.20

自引率

16.10%

发文量

163

审稿时长

6-12 weeks

期刊介绍： Neuroscience Bulletin (NB), the official journal of the Chinese Neuroscience Society, is published monthly by Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Springer. NB aims to publish research advances in the field of neuroscience and promote exchange of scientific ideas within the community. The journal publishes original papers on various topics in neuroscience and focuses on potential disease implications on the nervous system. NB welcomes research contributions on molecular, cellular, or developmental neuroscience using multidisciplinary approaches and functional strategies. We feature full-length original articles, reviews, methods, letters to the editor, insights, and research highlights. As the official journal of the Chinese Neuroscience Society, which currently has more than 12,000 members in China, NB is devoted to facilitating communications between Chinese neuroscientists and their international colleagues. The journal is recognized as the most influential publication in neuroscience research in China.