Evasive mechanisms of human VSG and PfEMP1 antigens with link to Vaccine scenario: a review.

Abstract

Recent fights on the control of trypanosomiasis and malaria focused on underscoring the concepts of antigen evasive mechanisms with the view to exploit the defensive mechanisms inherent in VSG and PfEMP1, although giant strides is being achieved towards beating the antigenic propensity of malaria parasites. Trypanosoma and Plasmodium falciparum adopt a common antigenic novelty through alternate expression of VSG and PfEMP1 respectively. These immunodominant antigens sterically shield other surface proteins from host antibodies and unvaryingly turn out to be the requisite elements with difficult underlining immunological concept for unmatched escape mechanisms of vaccine actions. Hence, the uncommon role of the pathogens to brazenly circumnavigate immunity through switching of variant antigens has not kept pace. Switching of variant surface in human trypanosomes occurs through programmed DNA rearrangements while in P. falciparum, switching occurs by purely transcriptional mechanism. The repertoire genes harmonize evasion of human immunity and also rekindle the outcome of infections. The extensive sequence divergence and genetic polymorphism of VSG and PfEMP1 are the requisite elements for the next generation breakthrough in vaccine discoveries. Thus, the springboard for the development of novel targets is lurking with the wit of unraveling the immunological concepts underlining the evasive aptitude of VSG and PfEMP1 with convincing biochemical techniques, hence offering a blueprint for enhanced vaccine targets. This review elucidates evasive mechanisms of VSG and PfEMP1 with link to pathologies, challenges of antigenic switches and prospects to current vaccine scenario.