Improving recruitment and retention of people with Parkinson's disease to clinical studies: A scoping review.

IF 4 3区 医学 Q2 NEUROSCIENCES
Journal of Parkinson's disease Pub Date : 2025-02-01 Epub Date: 2025-01-14 DOI:10.1177/1877718X241291986
Rebecca Petty, Veena Agarwal, Jennifer Allison, Sandra Bartolomeu-Pires, Michèle Bartlett, Timothy Boey, Rebecca Croucher, Helen Collins, Sally Collins, Emma Davies, Joy Duffen, Romy Ellis-Doyle, Cristina Gonzalez-Robles, Jemma Inches, Georgia Mills, Sheila Wonnacott, Thomas Foltynie, Victoria Allgar, Tom Thompson, Camille B Carroll, Stephen Mullin, Marie Louise-Zeissler
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引用次数: 0

Abstract

BackgroundTimely recruitment and effective retention of participants are challenging for clinical Parkinson's disease (PD) research studies. Not achieving this can affect delivery costs and bias results.ObjectiveTo identify successful recruitment and retention methodologies for clinical research studies in PD.MethodsWe conducted a systematic scoping review using a Population, Intervention, Comparator, Outcome and Study design (PICOS) framework to search and screen literature within five databases for published quantitative and mixed methods studies evaluating recruitment and retention strategies of interventional and observational trials in PD.ResultsSearches identified 4608 records, of which six papers covering eight studies were included in the review following screening for eligibility. No papers on retention strategies were found that met eligibility criteria. Effective strategies for rapid recruitment included research registries and trial finders (n = 3), digital marketing campaigns (n = 3), site recruitment support (n = 1) and multiple referral sources (n = 1). Recruitment diversity was increased by online campaigns, mandatory 10% minority targets set by funders and supplemental site funding.ConclusionsThis scoping review has identified methods that can be used to increase the rate and diversity of recruitment to PD clinical studies. Retention methodologies are under-researched.

改善帕金森病患者临床研究的招募和保留:一项范围综述。
背景:及时招募和有效保留参与者是临床帕金森病(PD)研究的挑战。没有做到这一点可能会影响交付成本和偏差结果。目的:为帕金森病的临床研究确定成功的招募和保留方法。方法:我们使用人口、干预、比较器、结果和研究设计(PICOS)框架进行了系统的范围审查,在5个数据库中搜索和筛选已发表的定量和混合方法研究文献,评估PD干预和观察试验的招募和保留策略。结果:检索到4608条记录,其中6篇论文涵盖了8项研究,在筛选合格性后纳入了综述。没有找到符合资格标准的关于保留战略的文件。快速招聘的有效策略包括研究注册和试验研究者(n = 3)、数字营销活动(n = 3)、网站招聘支持(n = 1)和多种推荐来源(n = 1)。通过在线活动、由资助者设定的10%的少数族裔强制性目标和补充的网站资助,增加了招聘的多样性。结论:本综述确定了可用于增加PD临床研究招募率和多样性的方法。留存方法尚未得到充分研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.40
自引率
5.80%
发文量
338
审稿时长
>12 weeks
期刊介绍: The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.
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