Extracellular vesicles: their challenges and benefits as potential biomarkers for musculoskeletal disorders.

IF 1.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Soo-Eun Sung, Min-Soo Seo, Wook-Tae Park, Young-Ju Lim, Sangbum Park, Gun Woo Lee
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引用次数: 0

Abstract

Early diagnosis and timely management are critical for determining disease outcomes and prognoses. To date, certain methods for developing disease-specific biomarkers have been reported; however, strategies for musculoskeletal disease-specific biomarker development have rarely been studied. Recent studies have highlighted the potential application of extracellular vesicles (EVs) as disease-specific biomarkers. EVs encapsulate proteins, lipids, messenger RNAs, and microRNAs derived from their cellular origin; these constituents remain stable within the EVs and can traverse the blood-brain barrier. Because of these distinctive characteristics, EVs have been actively investigated as diagnostic tools for various conditions, including cancer, inflammatory diseases, and musculoskeletal disorders. Although EVs have many advantages for biomarker development, they have not yet been fully researched in the context of musculoskeletal pathologies. The current review aimed to highlight the potential of EVs in the development of disease-specific biomarkers, summarize the processes of EV biomarkers, and discuss current limitations and future perspectives of EVs as biomarkers.

细胞外囊泡:作为肌肉骨骼疾病潜在生物标志物的挑战和益处。
早期诊断和及时管理对于确定疾病结局和预后至关重要。迄今为止,已经报道了开发疾病特异性生物标志物的某些方法;然而,肌肉骨骼疾病特异性生物标志物开发的策略很少被研究。最近的研究强调了细胞外囊泡(EVs)作为疾病特异性生物标志物的潜在应用。电动汽车封装蛋白质、脂质、信使rna和来自细胞起源的microrna;这些成分在ev内保持稳定,并能穿过血脑屏障。由于这些独特的特征,电动汽车已被积极研究作为各种疾病的诊断工具,包括癌症、炎症性疾病和肌肉骨骼疾病。尽管电动汽车在生物标志物开发方面具有许多优势,但它们尚未在肌肉骨骼病理学背景下得到充分研究。本文旨在强调EV在疾病特异性生物标志物开发中的潜力,总结EV生物标志物的开发过程,并讨论EV作为生物标志物的局限性和未来前景。
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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
555
审稿时长
1 months
期刊介绍: _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605
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