Reference Interval Establishment for Neutrophil-To-Lymphocyte Ratio, Platelet-To-Lymphocyte Ratio, and Systemic Immune-Inflammation Index in Athletes: Analysis of Sex and Sport Type Impact.

IF 2.6 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Journal of Clinical Laboratory Analysis Pub Date : 2025-02-20 DOI:10.1002/jcla.70005

Cong Wang, Zhengmei Ning, Qi Lu, Jianya Huang, Guoqing Yuan, Junfei Chen, Gang Liu

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引用次数: 0

Abstract

Objective: To establish sex- and sport-specific reference intervals (RIs) for the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) in athletes.

Methods: A retrospective study analyzed 13,647 entries from elite athletes (2018-2024), categorized by sex and six sport types. RIs were developed using a training set (9555 entries) and validated with a separate set (4092 entries). The RIs were defined using the 2.5th and 97.5th percentiles of the distribution.

Results: Females had higher RIs compared to males: NLR (females: 1.53 [0.74, 3.25]; males: 1.36 [0.70, 2.89]), PLR (females: 124 [69, 223]; males: 111 [65, 188]), and SII (females: 347 [146, 804]; males: 298 [139, 684]) (p < 0.001). Sport type influenced RIs, with significant differences noted across categories (p < 0.001). Validation showed an outlier rate below 10% across all groups, confirming robustness.

Conclusion: These sex- and sport-specific RIs enhance the precision of health assessments, supporting early detection of overtraining and inflammation in athletes. Future studies should expand to diverse populations and consider factors like age and training cycles.

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来源期刊

Journal of Clinical Laboratory Analysis 医学-医学实验技术

CiteScore

5.60

自引率

7.40%

发文量

584

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.