{"title":"Detection of Four Cases of Familial Hypercholesterolemia during a Workers' Compensation Insurance Secondary Health Examination.","authors":"Takayuki Yamaji, Aya Mizobuchi, Yukihito Higashi","doi":"10.2169/internalmedicine.4790-24","DOIUrl":null,"url":null,"abstract":"<p><p>Familial hypercholesterolemia (FH), a genetic disorder characterized by the early onset of coronary artery disease, is found in one of 300 people. In the 2022 Japanese FH guidelines, a cut-off value for Achilles tendon thickness measured using ultrasound has been added, enabling the diagnosis of FH during a Workers' Compensation Insurance Secondary Health Examination. In individuals for whom the possibility of FH could not be ruled out based on low-density lipoprotein cholesterol levels, we measured the Achilles tendon thickness by ultrasound and found four cases of FH. The detection of FH in asymptomatic workers is crucial for long-term cardiovascular risk management.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2610-2614"},"PeriodicalIF":1.1000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463420/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Internal Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2169/internalmedicine.4790-24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/21 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Familial hypercholesterolemia (FH), a genetic disorder characterized by the early onset of coronary artery disease, is found in one of 300 people. In the 2022 Japanese FH guidelines, a cut-off value for Achilles tendon thickness measured using ultrasound has been added, enabling the diagnosis of FH during a Workers' Compensation Insurance Secondary Health Examination. In individuals for whom the possibility of FH could not be ruled out based on low-density lipoprotein cholesterol levels, we measured the Achilles tendon thickness by ultrasound and found four cases of FH. The detection of FH in asymptomatic workers is crucial for long-term cardiovascular risk management.
期刊介绍:
Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine.
Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.