Unveiling the role of FOXL2 in female differentiation and disease: a comprehensive review†.

IF 3.1 2区生物学 Q2 REPRODUCTIVE BIOLOGY

Biology of Reproduction Pub Date : 2025-04-13 DOI:10.1093/biolre/ioaf013

Jia He, Zican Wang, Lici Yang, Yongjian Jiang, Ge Yan, Yongwei Pan, Fei Gao, Jinxiang Yuan, Yang Gao

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引用次数: 0

Abstract

Ovarian differentiation relies on the accurate and orderly expression of numerous related genes. Forkhead box protein L2 (FOXL2) is one of the earliest ovarian differentiation markers and transcription factors. In sex determination, FOXL2 maintains the differentiation of the female pathway by inhibiting male differentiation genes, including SOX9 and SF1. In addition, FOXL2 promotes the synthesis of follicle-stimulating hormone and anti-Müllerian hormone to support follicle development. Mutations in FOXL2 are associated with numerous female reproductive diseases. A comprehensive and in-depth study of FOXL2 provides novel strategies for the diagnosis and treatment of such diseases. This review discusses the mechanism of FOXL2 in female sex differentiation and maintenance, hormone synthesis, and disease occurrence and reveals the role of FOXL2 as a central factor in female sex development and fertility maintenance. This review will serve as a reference for identifying novel targets of other regulatory factors interacting with FOXL2 in female sex determination and follicle development and for the diagnosis and treatment of female reproductive diseases.

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揭示FOXL2在女性分化和疾病中的作用：综述

卵巢分化依赖于众多相关基因的准确有序表达。叉头盒蛋白L2 （FOXL2）是最早的卵巢分化标志物和转录因子之一。在性别决定中，FOXL2通过抑制包括SOX9和SF1在内的雄性分化基因来维持雌性通路的分化。此外，FOXL2促进促卵泡激素和抗卵泡激素的合成，以支持卵泡发育。FOXL2突变与许多女性生殖疾病有关。对FOXL2的全面深入研究为此类疾病的诊断和治疗提供了新的策略。本文就FOXL2在女性性别分化与维持、激素合成和疾病发生中的作用机制进行了综述，揭示了FOXL2在女性性别发育和生育维持中的核心作用。本综述将为发现与FOXL2相互作用的其他调控因子在女性性别决定和卵泡发育中的新靶点以及女性生殖疾病的诊断和治疗提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biology of Reproduction 生物-生殖生物学

CiteScore

6.30

自引率

5.60%

发文量

214

审稿时长

1 months

期刊介绍： Biology of Reproduction (BOR) is the official journal of the Society for the Study of Reproduction and publishes original research on a broad range of topics in the field of reproductive biology, as well as reviews on topics of current importance or controversy. BOR is consistently one of the most highly cited journals publishing original research in the field of reproductive biology.