Unveiling the role of FOXL2 in female differentiation and disease: a comprehensive review.

IF 3.1 2区生物学 Q2 REPRODUCTIVE BIOLOGY

Biology of Reproduction Pub Date : 2025-02-20 DOI:10.1093/biolre/ioaf013

Jia He, Zican Wang, Lici Yang, Yongjian Jiang, Ge Yan, Yongwei Pan, Fei Gao, Jinxiang Yuan, Yang Gao

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引用次数: 0

Abstract

Ovarian differentiation relies on the accurate and orderly expression of numerous related genes. Forkhead box protein L2 (FOXL2) is one of the earliest ovarian differentiation markers and transcription factors. In sex determination, FOXL2 maintains the differentiation of the female pathway by inhibiting male differentiation genes, including SOX9 and SF1. In addition, FOXL2 promotes the synthesis of follicle-stimulating hormone and anti-Müllerian hormone to support follicle development. Mutations in FOXL2 are associated with numerous female reproductive diseases. A comprehensive and in-depth study of FOXL2 provides novel strategies for the diagnosis and treatment of such diseases. This review discusses the mechanism of FOXL2 in female sex differentiation and maintenance, hormone synthesis, and disease occurrence and reveals the role of FOXL2 as a central factor in female sex development and fertility maintenance. This review will serve as a reference for identifying novel targets of other regulatory factors interacting with FOXL2 in female sex determination and follicle development and for the diagnosis and treatment of female reproductive diseases.

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来源期刊

Biology of Reproduction 生物-生殖生物学

CiteScore

6.30

自引率

5.60%

发文量

214

审稿时长

1 months

期刊介绍： Biology of Reproduction (BOR) is the official journal of the Society for the Study of Reproduction and publishes original research on a broad range of topics in the field of reproductive biology, as well as reviews on topics of current importance or controversy. BOR is consistently one of the most highly cited journals publishing original research in the field of reproductive biology.