The Impact of Radiation Dose on CT-Based Body Composition Analysis: A Large-Animal Study

IF 9.4 1区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Cachexia Sarcopenia and Muscle Pub Date : 2025-02-20 DOI:10.1002/jcsm.13741

Luca Salhöfer, Gregor Jost, Mathias Meetschen, Daniel van Landeghem, Michael Forsting, Denise Bos, Christian Bojahr, Rene Hosch, Felix Nensa, Hubertus Pietsch, Johannes Haubold

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Abstract

Background

CT-based body composition analysis (BCA) enables the extraction of biomarkers from routine CT data. The influence of body composition on the prognosis of different patient groups has been highlighted in recent years. Typically, the segmentation of muscle and fat compartments is performed with a thresholding-based subsegmentation, which might be influenced by the image noise as a function of radiation dose. This study was performed to investigate the impact of the radiation dose on a fully automated, volumetric CT-based BCA.

Methods

In this animal study, 20 Göttingen minipigs were subjected to CT scans on six occasions under five different dose settings with gradations compared to the control given in % from volumetric CT dose index (CTDIvol) of the control (5%, 10%, 20%, 40%, control [10.01 mGy]). A database with full dose (FD) and quarter dose (QD) CT scans from The Cancer Imaging Archive served as a human validation cohort. A previously open-source published and validated BCA network was applied to each scan. The following features were extracted as volumes (mL): bone, muscle, subcutaneous adipose tissue (SAT), intermuscular and intramuscular adipose tissue (IMAT), visceral adipose tissue (VAT) and total adipose tissue (TAT). Statistical significance was assessed by a one-way ANOVA with Tukey's multiple comparisons or Kruskal–Wallis with Dunn's post-hoc tests. The correlation between feature volumes in the dose gradations and the control group was analysed using the Spearman or Pearson method.

Results

All BCA features remained consistent up to the 10% group and showed no significant differences compared with the control. In the lowest dose group (5%), there were significant differences concerning the muscle (5% = 1295 mL [211 mL], control = 1338 mL [248 mL]; p = 0.032) and VAT volumetry (5% = 353 mL [208 mL], control = 312 mL [204 mL]; p = 0.026) with median differences of −3.13% (muscle) and 12.3% (VAT), respectively. Significant and strong positive correlations were observed between all low-dose groups and the control (r > 0.977, p < 0.001). The human validation analysis yielded constant volumes for every BCA feature with a strong positive correlation (r > 0.933, p < 0.001).

Conclusions

Fully automated BCA maintains consistent results in various low-dose settings. Significant deviations are only observed after more than 90% dose reduction in the lowest dose settings (5%), which are currently not used in the clinical routine. This large-animal study demonstrates the consistency of fully automated BCA in different dose settings and may therefore facilitate its integration into the clinical routine.

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辐射剂量对基于ct的体成分分析的影响：一项大型动物研究

基于CT的身体成分分析（BCA）能够从常规CT数据中提取生物标志物。近年来，身体成分对不同患者群体预后的影响日益受到重视。通常，肌肉和脂肪区室的分割是基于阈值的细分，这可能会受到图像噪声作为辐射剂量函数的影响。本研究的目的是研究辐射剂量对全自动容积ct - BCA的影响。方法在这项动物研究中，20只Göttingen迷你猪在5种不同剂量设置下进行了6次CT扫描，并与对照组进行了分级，以对照（5%,10%,20%,40%，对照[10.01 mGy]）的CT体积剂量指数（CTDIvol）的百分比为单位。来自癌症影像档案的全剂量（FD）和四分之一剂量（QD） CT扫描数据库作为人类验证队列。每次扫描都应用了先前公开发布并经过验证的BCA网络。以体积（mL）提取以下特征：骨、肌肉、皮下脂肪组织（SAT）、肌间和肌内脂肪组织（IMAT）、内脏脂肪组织（VAT）和总脂肪组织（TAT）。采用Tukey多重比较或Kruskal-Wallis与Dunn事后检验的单因素方差分析评估统计显著性。采用Spearman或Pearson方法分析剂量级配中特征体积与对照组的相关性。结果10%组BCA特征保持一致，与对照组比较无显著差异。最低剂量组（5%）肌肉组差异有统计学意义(5% = 1295 mL [211 mL]，对照组= 1338 mL [248 mL]；p = 0.032)和VAT容积法(5% = 353 mL [208 mL]，对照组= 312 mL [204 mL]；p = 0.026)，中位数差异分别为- 3.13%（肌肉）和12.3% （VAT）。各低剂量组与对照组之间存在显著且强的正相关（r > 0.977, p < 0.001）。人体验证分析为每个BCA特征提供了恒定的体积，具有很强的正相关性（r > 0.933, p < 0.001）。结论：全自动BCA在各种低剂量设置下保持一致的结果。只有在最低剂量设置（5%）的剂量减少超过90%后才会观察到显著偏差，目前在临床常规中未使用最低剂量设置。这项大型动物研究证明了全自动BCA在不同剂量设置下的一致性，因此可能有助于将其纳入临床常规。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cachexia Sarcopenia and Muscle MEDICINE, GENERAL & INTERNAL-

CiteScore

13.30

自引率

12.40%

发文量

234

审稿时长

16 weeks

期刊介绍： The Journal of Cachexia, Sarcopenia and Muscle is a peer-reviewed international journal dedicated to publishing materials related to cachexia and sarcopenia, as well as body composition and its physiological and pathophysiological changes across the lifespan and in response to various illnesses from all fields of life sciences. The journal aims to provide a reliable resource for professionals interested in related research or involved in the clinical care of affected patients, such as those suffering from AIDS, cancer, chronic heart failure, chronic lung disease, liver cirrhosis, chronic kidney failure, rheumatoid arthritis, or sepsis.