Detection of Respiratory Viruses Other Than SARS-CoV-2 in a Large Hospital Laboratory in Rome, Italy, During the Seasons 2016–2017 to 2022–2023

IF 4.2 4区医学 Q1 INFECTIOUS DISEASES

Influenza and Other Respiratory Viruses Pub Date : 2025-02-20 DOI:10.1111/irv.70079

Flora Marzia Liotti, Simona Marchetti, Sara D'Onghia, Maurizio Sanguinetti, Rosaria Santangelo, Brunella Posteraro

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Abstract

Background and Objective

Respiratory viruses are major contributors to morbidity and mortality worldwide, with their circulation influenced by seasonal patterns and pandemic-related interventions. This study analyzed detection trends of non-SARS-CoV-2 respiratory viruses in a large Italian hospital over a 7-year period, focusing on variations across COVID-19–related periods and patient age groups.

Methods

We retrospectively analyzed multiplex PCR-based laboratory results of 8836 nasopharyngeal samples collected between September 2016 and August 2023. Viral detection rates were stratified by season, COVID-19–related periods (pre-pandemic, pandemic, post-pandemic), and age groups.

Results

Of the 8836 nasopharyngeal samples analyzed, 2795 (31.6%) tested positive for at least one respiratory virus. Rhinovirus/enterovirus (RV/EV) was the most frequently detected virus (37.6%), followed by influenza A virus (IAV, 17.9%) and respiratory syncytial virus (RSV, 17.2%). The 2020–2021 season had the lowest positivity rate (p < 0.001), with marked declines in IAV and RSV detections, likely because of COVID-19 mitigation measures. Conversely, detections of RV/EV and human coronaviruses increased. Postpandemic data suggested a return to prepandemic patterns, though overall positivity rates remained altered. Age-stratified analysis revealed RSV predominance in infants (p < 0.001), emphasizing its clinical relevance in pediatric populations.

Conclusions

Our findings highlight the dynamic nature of respiratory virus epidemiology and the persistent impact of the COVID-19 pandemic on viral circulation. Continuous surveillance and adaptive public health strategies are essential for managing future outbreaks and mitigating the burden of respiratory viral infections.

Abstract Image

查看原文本刊更多论文

2016-2017年至2022-2023年季节意大利罗马某大型医院实验室非SARS-CoV-2呼吸道病毒检测

背景和目的呼吸道病毒是全世界发病率和死亡率的主要原因，其传播受到季节模式和与大流行有关的干预措施的影响。本研究分析了意大利一家大型医院7年来非sars - cov -2呼吸道病毒的检测趋势，重点关注了covid -19相关时期和患者年龄组的变化。方法回顾性分析2016年9月至2023年8月采集的8836份鼻咽标本的多重pcr检测结果。病毒检出率按季节、与covid -19相关的时期（大流行前、大流行前、大流行后）和年龄组分层。结果8836份鼻咽样本中，2795份（31.6%）至少检测出一种呼吸道病毒。鼻病毒/肠病毒（RV/EV）是最常见的病毒（37.6%），其次是甲型流感病毒（IAV）（17.9%）和呼吸道合胞病毒（RSV）（17.2%）。2020-2021年季节的阳性率最低（p < 0.001）， IAV和RSV检测显着下降，可能是由于COVID-19缓解措施。相反，RV/EV和人冠状病毒的检出率增加。大流行后的数据表明，虽然总体阳性率仍有变化，但已恢复到大流行前的模式。年龄分层分析显示RSV在婴儿中占优势（p < 0.001），强调其在儿科人群中的临床相关性。结论本研究结果突出了呼吸道病毒流行病学的动态性质以及COVID-19大流行对病毒循环的持续影响。持续监测和适应性公共卫生战略对于管理未来的疫情和减轻呼吸道病毒感染的负担至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.