Muzammil Kuddushi, Tanay Kumar, Hongyan Wu, Sherry Chen, Ben Bin Xu, Naved Malek, Larry Unsworth, Jiangtao Xu, Jiangwen Zhang, Xihua Wang, Xuehua Zhang
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引用次数: 0
Abstract
Wound healing is a critical process that significantly impacts patient health and places a substantial burden on healthcare systems. This study aimed to develop and evaluate transparent composite nanofibrous membranes with enhanced biological functionality as advanced wound dressing materials. We hypothesized that the incorporation of sodium alginate (NaAlg) or zinc oxide (ZnO) into electrospun polymer nanofibers, combined with the use of a conductive aluminum mesh during fiber collection, would result in membranes with locally aligned nanofibers, enabling optical transparency, biocompatibility, and mechanical properties. By using a 1.58 mm aluminum square mesh as a fiber collector during electrospinning of polycaprolactone (PCL)/ethylene vinyl alcohol (EVOH), we fabricated composite fiber membranes with varying concentrations of NaAlg (1–5% w/v) or ZnO (1–3% w/v). The use of the conductive mesh led to partial alignment of the nanofibers, enhancing light transmission and achieving notable optical transparency (up to 40% for NaAlg and 22% for ZnO). These membranes also exhibited a bi-layer structural configuration, robust mechanical properties (12–13 MPa), and optimal water vapor transmission rates (WVTR, 1400–1700 g/m\(^{2}\)/day). Biological assessments, including disc diffusion and cytotoxicity tests, demonstrated excellent biocompatibility (85–100% viability with HaCaT cells) and promising blood-clotting properties. These findings suggest that the developed nanofiber membranes, through their unique alignment-driven transparency and multifunctionality, can effectively monitor wound healing in real-time, absorb substantial exudate, and provide a protective barrier against environmental contaminants. This work highlights the novelty and potential of these nanofiber membranes as advanced biomaterials for diverse wound dressing applications.
伤口愈合是一个重要的过程,对患者健康产生重大影响,并给医疗保健系统带来沉重负担。本研究旨在开发和评价具有增强生物功能的透明复合纳米纤维膜作为先进的伤口敷料材料。我们假设将海藻酸钠(NaAlg)或氧化锌(ZnO)掺入电纺丝聚合物纳米纤维中,并在纤维收集过程中使用导电铝网,将产生具有局部排列纳米纤维的膜,从而实现光学透明度、生物相容性和机械性能。在静电纺丝聚己内酯(PCL)/乙烯基醇(EVOH)过程中,采用1.58 mm铝方网作为纤维收集器,制备了不同浓度NaAlg(1-5)的复合纤维膜% w/v) or ZnO (1–3% w/v). The use of the conductive mesh led to partial alignment of the nanofibers, enhancing light transmission and achieving notable optical transparency (up to 40% for NaAlg and 22% for ZnO). These membranes also exhibited a bi-layer structural configuration, robust mechanical properties (12–13 MPa), and optimal water vapor transmission rates (WVTR, 1400–1700 g/m\(^{2}\)/day). Biological assessments, including disc diffusion and cytotoxicity tests, demonstrated excellent biocompatibility (85–100% viability with HaCaT cells) and promising blood-clotting properties. These findings suggest that the developed nanofiber membranes, through their unique alignment-driven transparency and multifunctionality, can effectively monitor wound healing in real-time, absorb substantial exudate, and provide a protective barrier against environmental contaminants. This work highlights the novelty and potential of these nanofiber membranes as advanced biomaterials for diverse wound dressing applications.
期刊介绍:
Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field.
The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest.
Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials.
Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.