Towards Non-Invasive Liver Health Monitoring: Comprehensive Microwave Dielectric Spectroscopy of Freshly Excised Human Abdominal Tissues

IF 3 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC
Md. Abdul Awal;Azin S. Janani;Sasan Ahdi Rezaeieh;Graeme A. Macdonald;Amin Abbosh
{"title":"Towards Non-Invasive Liver Health Monitoring: Comprehensive Microwave Dielectric Spectroscopy of Freshly Excised Human Abdominal Tissues","authors":"Md. Abdul Awal;Azin S. Janani;Sasan Ahdi Rezaeieh;Graeme A. Macdonald;Amin Abbosh","doi":"10.1109/JERM.2024.3416758","DOIUrl":null,"url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease ranks among the most prevalent chronic liver conditions worldwide. To reduce its burden, early diagnosis is vital to enable timely medication and rehabilitation. The non-invasive diagnosis of liver health is challenging due to the limitations of existing methods. For this purpose, the design of portable non-invasive electromagnetic sensors requires knowledge of how human liver tissue and other abdominal tissues interact with electromagnetic waves. This necessitates the accurate characterisation of dielectric properties of the liver and adjacent abdominal tissues. Since postmortem changes or prolonged storage significantly change those properties and lead to incorrect interpretation, fresh human abdominal tissues, including skin, fat, muscle, and liver, were obtained at surgery, and their dielectric properties were measured immediately in the microwave frequency range of 0.5 GHz to 15 GHz. An adaptive weighted vector mean optimization algorithm was used to derive the parameters of a second-order Cole-Cole model using the experimental data. Statistical and cluster analyses were performed on the curated database following the derived model. The results showed that hepatic steatosis significantly changed the dielectric properties of the liver <inline-formula><tex-math>$(p &lt; 0.001)$</tex-math></inline-formula>. Moreover, the liver had distinct dielectric properties from the skin, fat, and muscle tissues <inline-formula><tex-math>$(p &lt; 0.05)$</tex-math></inline-formula>. These findings suggest that electromagnetic sensors could be used to assess liver health in a non-invasive way, which could improve liver health outcomes and reduce costs.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":"9 1","pages":"2-14"},"PeriodicalIF":3.0000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://ieeexplore.ieee.org/document/10572299/","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0

Abstract

Metabolic dysfunction-associated steatotic liver disease ranks among the most prevalent chronic liver conditions worldwide. To reduce its burden, early diagnosis is vital to enable timely medication and rehabilitation. The non-invasive diagnosis of liver health is challenging due to the limitations of existing methods. For this purpose, the design of portable non-invasive electromagnetic sensors requires knowledge of how human liver tissue and other abdominal tissues interact with electromagnetic waves. This necessitates the accurate characterisation of dielectric properties of the liver and adjacent abdominal tissues. Since postmortem changes or prolonged storage significantly change those properties and lead to incorrect interpretation, fresh human abdominal tissues, including skin, fat, muscle, and liver, were obtained at surgery, and their dielectric properties were measured immediately in the microwave frequency range of 0.5 GHz to 15 GHz. An adaptive weighted vector mean optimization algorithm was used to derive the parameters of a second-order Cole-Cole model using the experimental data. Statistical and cluster analyses were performed on the curated database following the derived model. The results showed that hepatic steatosis significantly changed the dielectric properties of the liver $(p < 0.001)$. Moreover, the liver had distinct dielectric properties from the skin, fat, and muscle tissues $(p < 0.05)$. These findings suggest that electromagnetic sensors could be used to assess liver health in a non-invasive way, which could improve liver health outcomes and reduce costs.
迈向无创肝脏健康监测:新鲜切除人体腹部组织的综合微波介电光谱
代谢功能障碍相关的脂肪变性肝病是全球最普遍的慢性肝病之一。为了减轻其负担,早期诊断对于及时进行药物治疗和康复至关重要。由于现有方法的局限性,肝脏健康的非侵入性诊断是具有挑战性的。为此,便携式非侵入式电磁传感器的设计需要了解人体肝脏组织和其他腹部组织如何与电磁波相互作用。这就需要准确地描述肝脏和邻近腹部组织的介电特性。由于死后的变化或长时间的储存会显著改变这些特性并导致错误的解释,因此在手术中获得新鲜的人体腹部组织,包括皮肤、脂肪、肌肉和肝脏,并立即在0.5 GHz至15 GHz的微波频率范围内测量它们的介电特性。利用实验数据,采用自适应加权向量均值优化算法推导二阶Cole-Cole模型的参数。根据导出的模型对整理的数据库进行统计和聚类分析。结果表明,肝脏脂肪变性显著改变了肝脏的介电性质(p <;0.001)美元。此外,肝脏具有不同于皮肤、脂肪和肌肉组织的介电特性。0.05)美元。这些发现表明,电磁传感器可用于以非侵入性方式评估肝脏健康,这可以改善肝脏健康结果并降低成本。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
5.80
自引率
9.40%
发文量
58
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信