Modeling forebrain regional development and connectivity by human brain organoids

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2025-02-20 DOI:10.1016/j.gde.2025.102324

Mu Seog Choe , Cynthia Lo , In-Hyun Park

引用次数: 0

Abstract

The forebrain is one of the most important brain structures for modern human existence, which houses the uniquely sophisticated social and cognitive functions that distinguish our species. Therefore, modeling the forebrain development by using human cells is especially critical for our understanding of the intricacies of human development and devising treatments for related diseases. Recent advancements in brain organoid fields have offered unprecedented tools to investigate forebrain development from studies on specific regions to exploring tract formation and connectivity between different regions of the forebrain. In this review, we discuss the developmental biology of the forebrain and diverse methods for modeling its development by using organoids.

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用人脑类器官模拟前脑区域发育和连通性

前脑是现代人类存在的最重要的大脑结构之一，它容纳了独特的复杂的社会和认知功能，使我们的物种与众不同。因此，利用人类细胞对前脑发育进行建模对于我们理解人类发育的复杂性和设计相关疾病的治疗方法尤为重要。脑类器官领域的最新进展为研究前脑发育提供了前所未有的工具，从研究特定区域到探索前脑不同区域之间的束形成和连通性。在本文中，我们讨论了前脑的发育生物学和不同的方法来模拟其发展用类器官。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)