Irisin Modulates Perivascular Adipose Tissue Structure In Rat Thoracic Aorta

Q3 Medicine

Morphologie Pub Date : 2025-02-21 DOI:10.1016/j.morpho.2025.100955

A.T. Shatarat , A.M. Shurrab , H.M. Al-lahham , N.A. Tarboush , D.H. Badran , M.A. Salameh , R. Badran

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引用次数: 0

Abstract

Background

Irisin is a newly identified hormone secreted mainly by skeletal muscles. It has different effects on the cardiovascular system and blood vessels. The present study investigated the possible effects of irisin on the microscopic structure of the perivascular adipose tissue in the rat thoracic aorta.

Materials and methods

Twenty rats were randomly divided into two groups: a non-injected control group (n = 4) and four injected experimental groups (each n = 4). The experimental rats were injected intraperitoneally with one of the following concentrations of irisin; 250, 500, 1000, and 2000 ng/mL, twice a week for 4 weeks. After that, all experimental rats’ descending thoracic aortas were removed, and imaging was performed. ANOVA and Bonferroni's Multiple Comparison Test were used to achieve statistical comparisons.

Results

A trend of a dose-dependent increase in the number of brown adipocytes in all irisin-injected groups reached statistical significance at a dose of 2000 ng/mL, compared to that of the control group (from 7.9 ± 1 control to 67 ± 6.1 in 2000 ng/mL of irisin). A dose-dependent decrease in the number of white adipocytes compared to that of the control group (from 40 ± 4.8 control to 3 ± 0.9 in 2000 ng/mL of irisin).

Conclusion

The present study has for the first time demonstrated that irisin has significantly increased the number of brown adipocytes and decreased the number of white adipocytes in the perivascular adipose tissue in rat thoracic aorta.

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来源期刊

Morphologie Medicine-Anatomy

CiteScore

2.30

自引率

0.00%

发文量

150

审稿时长

25 days

期刊介绍： Morphologie est une revue universitaire avec une ouverture médicale qui sa adresse aux enseignants, aux étudiants, aux chercheurs et aux cliniciens en anatomie et en morphologie. Vous y trouverez les développements les plus actuels de votre spécialité, en France comme a international. Le objectif de Morphologie est d?offrir des lectures privilégiées sous forme de revues générales, d?articles originaux, de mises au point didactiques et de revues de la littérature, qui permettront notamment aux enseignants de optimiser leurs cours et aux spécialistes d?enrichir leurs connaissances.