Irisin Modulates Perivascular Adipose Tissue Structure In Rat Thoracic Aorta

Q3 Medicine

Morphologie Pub Date : 2025-02-21 DOI:10.1016/j.morpho.2025.100955

A.T. Shatarat , A.M. Shurrab , H.M. Al-lahham , N.A. Tarboush , D.H. Badran , M.A. Salameh , R. Badran

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引用次数: 0

Abstract

Background

Irisin is a newly identified hormone secreted mainly by skeletal muscles. It has different effects on the cardiovascular system and blood vessels. The present study investigated the possible effects of irisin on the microscopic structure of the perivascular adipose tissue in the rat thoracic aorta.

Materials and methods

Twenty rats were randomly divided into two groups: a non-injected control group (n = 4) and four injected experimental groups (each n = 4). The experimental rats were injected intraperitoneally with one of the following concentrations of irisin; 250, 500, 1000, and 2000 ng/mL, twice a week for 4 weeks. After that, all experimental rats’ descending thoracic aortas were removed, and imaging was performed. ANOVA and Bonferroni's Multiple Comparison Test were used to achieve statistical comparisons.

Results

A trend of a dose-dependent increase in the number of brown adipocytes in all irisin-injected groups reached statistical significance at a dose of 2000 ng/mL, compared to that of the control group (from 7.9 ± 1 control to 67 ± 6.1 in 2000 ng/mL of irisin). A dose-dependent decrease in the number of white adipocytes compared to that of the control group (from 40 ± 4.8 control to 3 ± 0.9 in 2000 ng/mL of irisin).

Conclusion

The present study has for the first time demonstrated that irisin has significantly increased the number of brown adipocytes and decreased the number of white adipocytes in the perivascular adipose tissue in rat thoracic aorta.

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鸢尾素对大鼠胸主动脉血管周围脂肪组织结构的调节作用

risin是一种新发现的主要由骨骼肌分泌的激素。它对心血管系统和血管有不同的影响。本研究探讨鸢尾素对大鼠胸主动脉血管周围脂肪组织微观结构的影响。材料与方法将20只大鼠随机分为两组：未注射对照组（n = 4）和4个注射实验组（每组n = 4）。实验大鼠腹腔注射鸢尾素浓度：250、500、1000、2000 ng/mL，每周两次，连续4周。之后，切除所有实验大鼠的胸降主动脉，进行影像学检查。采用方差分析和Bonferroni多重比较检验进行统计学比较。结果2000 ng/mL鸢尾素注射组棕色脂肪细胞数量均呈剂量依赖性增加趋势，与对照组相比（2000 ng/mL鸢尾素注射组从7.9±1个对照组增加到67±6.1个对照组），差异均有统计学意义。与对照组相比，白色脂肪细胞数量呈剂量依赖性减少（在2000 ng/mL鸢尾素中，从40±4.8个对照组减少到3±0.9个）。结论本研究首次证实鸢尾素能显著增加大鼠胸主动脉血管周围脂肪组织中棕色脂肪细胞的数量，降低白色脂肪细胞的数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Morphologie Medicine-Anatomy

CiteScore

2.30

自引率

0.00%

发文量

150

审稿时长

25 days

期刊介绍： Morphologie est une revue universitaire avec une ouverture médicale qui sa adresse aux enseignants, aux étudiants, aux chercheurs et aux cliniciens en anatomie et en morphologie. Vous y trouverez les développements les plus actuels de votre spécialité, en France comme a international. Le objectif de Morphologie est d?offrir des lectures privilégiées sous forme de revues générales, d?articles originaux, de mises au point didactiques et de revues de la littérature, qui permettront notamment aux enseignants de optimiser leurs cours et aux spécialistes d?enrichir leurs connaissances.