Application and research progress of different frequency tACS in stroke rehabilitation: A systematic review

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-02-19 DOI:10.1016/j.brainres.2025.149521

Xue Ding , Yu Zhou , Yang Liu , Xiao-Ling Yao , Ji-Xian Wang , Qing Xie

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引用次数: 0

Abstract

After a stroke, abnormal changes in neural oscillations that are related to the severity and prognosis of the disease can occur. Resetting these abnormal neural oscillations is a potential approach for stroke rehabilitation. Transcranial alternating current stimulation (tACS) can modulate intrinsic neural oscillations noninvasively and has attracted attention as a possible technique to improve multiple post-stroke symptoms, including deficits in speech, vision, and motor ability and overall neurological recovery. The clinical effect of tACS varies according to the selected frequency. Therefore, choosing an appropriate frequency to optimize outcomes for specific dysfunctions is essential. This review focuses on the current research status and possibilities of tACS with different frequencies in stroke rehabilitation. We also discuss the possible mechanisms of tACS in stroke to provide a theoretical foundation for the method and highlight the controversial aspects that need further exploration. Although tACS has great potential, few clinical studies have applied it in the treatment of stroke, and no consensus has been reached. We analyze limitations in experimental designs and identify potential tACS approaches worthy of exploration in the future.

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.