Prevalence of narcolepsy in representative samples of the general population of North America, Europe, and South Korea

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research Pub Date : 2025-02-13 DOI:10.1016/j.psychres.2025.116390

Maurice M. Ohayon , Shreya Dave , Stephen Crawford , Todd J Swick , Marie-Lise Côté

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引用次数: 0

Abstract

Objectives

Narcolepsy is a rare, chronic, central disorder of hypersomnolence characterized by excessive daytime sleepiness, hypnagogic/hypnopompic hallucinations, sleep paralysis, disrupted nighttime sleep, and sometimes cataplexy (Type 1). The objective of this study was to assess the prevalence of narcolepsy in a large representative general population sample in North America, Europe, and Asia.

Methods

This cross-sectional epidemiological study utilized data from the Sleep-EVAL research database. The study involved 61,754 participants from 10 countries interviewed between 1992 and 2016 using the Sleep-EVAL Expert System, an artificial intelligence system designed to conduct interviews and perform positive and differential diagnoses based on interview responses. Using the answers provided for each symptom, the expert system built its diagnostic tree to reach a diagnostic conclusion of narcolepsy type 1 (NT1) or narcolepsy type 2 (NT2) for each participant according to the International Classification of Sleep Disorders, Third Edition, criteria.

Results

Overall, the prevalence of NT1 was estimated to be 19.1/100,000 persons and the prevalence of NT2 was 23.3/100,000 persons. Prevalence of NT1 and NT2 was similar between countries and between men and women. Highest prevalence was among participants aged 35 years or younger for NT1 and among participants aged 35−54 years for NT2.

Conclusions

Our study, based on data from the general populations of several countries, shows that narcolepsy is a rare disorder, affecting 42.4/100,000 persons.

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来源期刊

Psychiatry Research 医学-精神病学

CiteScore

17.40

自引率

1.80%

发文量

527

审稿时长

57 days

期刊介绍： Psychiatry Research offers swift publication of comprehensive research reports and reviews within the field of psychiatry. The scope of the journal encompasses: Biochemical, physiological, neuroanatomic, genetic, neurocognitive, and psychosocial determinants of psychiatric disorders. Diagnostic assessments of psychiatric disorders. Evaluations that pursue hypotheses about the cause or causes of psychiatric diseases. Evaluations of pharmacologic and non-pharmacologic psychiatric treatments. Basic neuroscience studies related to animal or neurochemical models for psychiatric disorders. Methodological advances, such as instrumentation, clinical scales, and assays directly applicable to psychiatric research.