Nanoengineered diagnostic surface for efficient detection of MMP1 cancer biomarkers

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research Pub Date : 2025-02-01 DOI:10.1016/j.sbsr.2025.100761

Graziele Cruzado , Alexis Marion , Edward Harvey , Geraldine Merle

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引用次数: 0

Abstract

Cancer, a global health concern, necessitates improved diagnostic tools for early detection and personalized treatment strategies. Matrix Metalloproteinases (MMPs), crucial in cancer progression, degrade the extracellular matrix (ECM) and facilitate metastasis. MMP1, notable for its role in ECM degradation and tumor promotion, is implicated in various cancers. Detecting MMP1 early offers critical insights into cancer progression and treatment efficacy. Traditional diagnostic methods are invasive and time-consuming, prompting the development of more efficient detection techniques. Here, we introduce an electrochemical peptide-based biosensor for sensitive MMP1 detection. Utilizing gold nanostructures to enhance surface area and signal-to-noise ratio, the biosensor employs ferrocene-labeled peptides sensitive to MMP1 hydrolysis, enabling voltammetric detection. This approach combines nanotechnology with electrochemical techniques for enhanced sensitivity and specificity, promising transformative impacts on cancer diagnostics. The biosensor exhibits a low limit of detection (LOD) of 0.27 ng/mL and demonstrates exceptional specificity towards MMP1, highlighting its potential for precise MMP1 detection in clinical applications.

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来源期刊

Sensing and Bio-Sensing Research Engineering-Electrical and Electronic Engineering

CiteScore

10.70

自引率

3.80%

发文量

审稿时长

87 days

期刊介绍： Sensing and Bio-Sensing Research is an open access journal dedicated to the research, design, development, and application of bio-sensing and sensing technologies. The editors will accept research papers, reviews, field trials, and validation studies that are of significant relevance. These submissions should describe new concepts, enhance understanding of the field, or offer insights into the practical application, manufacturing, and commercialization of bio-sensing and sensing technologies. The journal covers a wide range of topics, including sensing principles and mechanisms, new materials development for transducers and recognition components, fabrication technology, and various types of sensors such as optical, electrochemical, mass-sensitive, gas, biosensors, and more. It also includes environmental, process control, and biomedical applications, signal processing, chemometrics, optoelectronic, mechanical, thermal, and magnetic sensors, as well as interface electronics. Additionally, it covers sensor systems and applications, µTAS (Micro Total Analysis Systems), development of solid-state devices for transducing physical signals, and analytical devices incorporating biological materials.