3D-printed PLA/Fe3O4/MgO hybrid composite scaffolds with improved properties

Q1 Computer Science

Bioprinting Pub Date : 2025-02-16 DOI:10.1016/j.bprint.2025.e00398

Reyhaneh Ramezani , Reza Alizadeh , Sheyda Labbaf

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引用次数: 0

Abstract

Fused deposition modeling was successfully used to print porous scaffolds, using filaments of pure PLA, PLA/15 wt% Fe₃O₄ and PLA/15 wt% Fe₃O₄/5 wt% MgO. The magnetic, mechanical, thermal, and cellular properties of these samples were systematically evaluated and compared. The findings reveal that incorporating Fe₃O₄ enhances the magnetization saturation of PLA without compromising its mechanical and thermal integrity. Moreover, weight loss tests in phosphate-buffered saline solution indicated that the PLA/Fe₃O₄/MgO composite showed the highest degradation rate after 65 days. Biological assays confirmed enhanced cell adhesion and viability for the PLA/Fe₃O₄ and PLA/Fe₃O₄/MgO composites compared to pure PLA. These results demonstrate that the PLA/Fe₃O₄ and PLA/Fe₃O₄/MgO composites are promising alternatives of pure PLA for biomedical applications, addressing its inherent limitations, especially in cases where detection of implant by X-ray is required after implantation.

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3d打印性能改善的PLA/Fe3O4/MgO杂化复合材料支架

使用纯PLA、PLA/15 wt% Fe3O4和PLA/15 wt% Fe3O4/5 wt% MgO的长丝，熔融沉积模型成功地用于打印多孔支架。系统地评价和比较了这些样品的磁性、力学、热学和细胞性质。研究结果表明，加入Fe3O4可以提高PLA的磁化饱和度，但不会影响其机械和热完整性。此外，在磷酸盐缓冲盐水溶液中的失重试验表明，PLA/Fe3O4/MgO复合材料在65天后的降解率最高。生物实验证实，与纯PLA相比，PLA/Fe3O4和PLA/Fe3O4/MgO复合材料增强了细胞粘附性和活力。这些结果表明PLA/Fe3O4和PLA/Fe3O4/MgO复合材料是纯PLA在生物医学应用中的有希望的替代品，解决了其固有的局限性，特别是在植入后需要x射线检测植入物的情况下。

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来源期刊

Bioprinting Computer Science-Computer Science Applications

CiteScore

11.50

自引率

0.00%

发文量

审稿时长

68 days

期刊介绍： Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.