Evaluation of the Potential of a Ratiometric Fluorescence Sensor for Sensitively Recognizing 1-Hydroxypyrene in Real Urine Samples Based on a Stable Zn-MOF

IF 4.3 2区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Pub Date : 2025-02-20 DOI:10.1021/acs.inorgchem.4c05281

Shuting Xu, Junxi Liu, Bo Zhang, Jiandong Pang, Yan Yang, Jun Li

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Abstract

In the work, a 3D Zn-based MOF, [CH₃(NH₂)₂][Zn₂(obdb)(OH)]·DMF (compound 1) has been formed successfully through the self-assembly of Zn(II) ion and organic linker H₄obdb (4′,4‴-oxybis[1,1′-biphenyl]-3,5-dicarboxylic acid, a high-symmetrical tetra-carboxylate ligand) under solvothermal conditions. In the structure of compound 1, Zn and the symmetry-generated ones constitute a tetra-nuclear cluster [Zn₄(μ₂-COO)₈(μ₃–OH)₂], and then by the coordination of tetra-nuclear clusters and the organic linkers, a 3D stair-like framework containing a 1D rectangular channel with the porosity of 47.3% is generated. Interestingly, compound 1 is confirmed to possess striking air and pH stability. Noteworthily, the results of detecting studies certify that compound 1 can serve as a prospective ratiometric fluorescence sensor for selectively recognizing 1-hydroxypyrene (1-HP) among diverse urine components and a promising fluorescence probe for Asp from other 11 kinds of amino acids depended on “turn-off” effects decorated with high quenching efficiencies (97.5% for 1-HP and 94.3% for Asp) and outstanding sensitivity with K_sv values of 1.84 × 10⁵ M^–1 for 1-HP and 1.41 × 10⁴ M^–1 for Asp in a DMF-H₂O binary system. Amazingly, the sensing capacities of compound 1 maintain similar levels in fresh human urine compared with those in the DMF-H₂O binary system, giving the K_sv values of 5.79 × 10⁴ M^–1 for 1-HP and 1.72 × 10⁴ M^–1 for Asp.

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来源期刊

Inorganic Chemistry 化学-无机化学与核化学

CiteScore

7.60

自引率

13.00%

发文量

1960

审稿时长

1.9 months

期刊介绍： Inorganic Chemistry publishes fundamental studies in all phases of inorganic chemistry. Coverage includes experimental and theoretical reports on quantitative studies of structure and thermodynamics, kinetics, mechanisms of inorganic reactions, bioinorganic chemistry, and relevant aspects of organometallic chemistry, solid-state phenomena, and chemical bonding theory. Emphasis is placed on the synthesis, structure, thermodynamics, reactivity, spectroscopy, and bonding properties of significant new and known compounds.