Microplastics and Nanoplastics Increase Major Adverse Cardiac Events in Patients with Myocardial Infarction

IF 11.3 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2025-02-19 DOI:10.1016/j.jhazmat.2025.137624

Yun Zhang, Qianhui Gao, Qiang Gao, Mingcheng Xu, Ning Fang, Lin Mu, Xuejie Han, Hui Yu, Song Zhang, Yue Li, Yongtai Gong

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Abstract

Microplastics and nanoplastics (MNPs) have implicated in cardiovascular disease in preclinical studies. Our objective is to investigate the relationship between MNPs iin the coronary arteries and major adverse cardiac events (MACE) in patients with myocardial infarction (MI).We conducted a prospective observational study involving patients undergoing coronary angiography for MI. Coronary blood samples were analyzed for the presence of MNPs using pyrolysis–gas chromatography–mass spectrometry. A total of 142 patients were enrolled, with 110 completing a 31.5-month follow-up. Among them, 48 (43.6%) had detectable polystyrene, 79 (71.8%) had polyethylene, 105 (95.4%) had polyvinyl chloride (PVC), and 68 (61.8%) had polyamide 66 in their coronary blood. PVC concentration was higher in patients who experienced MACE. Furthermore, PVC levels were positively associated with proinflammatory factors (IL-1β, IL-6, IL-18, and TNF-α), and associated with higher odds of MACE (OR: 1.090, 95%CI: 1.032-1.1523, P=0.002). Notably, for each 10-unit increase in PVC, there was a 1.374-fold increase in the risk of MACE (OR=2.374, 95%CI: 1.366-4.128, P=0.002). Additionally, we collected blood and thrombus samples from an additional 21 MI patients, finding that PVC levels in coronary thrombi were positively correlated with inflammatory markers and monocyte/macrophage infiltration.

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微塑料和纳米塑料增加心肌梗死患者的主要不良心脏事件

在临床前研究中，微塑料和纳米塑料（MNPs）与心血管疾病有关。我们的目的是研究冠状动脉中MNPs与心肌梗死（MI）患者主要不良心脏事件（MACE）之间的关系。我们对接受心肌梗死冠脉造影的患者进行了一项前瞻性观察研究。冠状动脉血液样本采用热解-气相色谱-质谱法分析了MNPs的存在。共有142名患者入组，其中110名完成了31.5个月的随访。其中聚苯乙烯48例（43.6%），聚乙烯79例（71.8%），聚氯乙烯105例（95.4%），聚酰胺66 68例（61.8%）。经历MACE的患者的PVC浓度较高。此外，PVC水平与促炎因子（IL-1β、IL-6、IL-18和TNF-α）呈正相关，并与MACE发生率升高相关（OR: 1.090, 95%CI: 1.032-1.1523， P=0.002）。值得注意的是，每增加10个单位的PVC， MACE的风险增加1.374倍（OR= 2.3774, 95%CI: 1.366-4.128， P=0.002）。此外，我们收集了另外21例心肌梗死患者的血液和血栓样本，发现冠状动脉血栓中的PVC水平与炎症标志物和单核细胞/巨噬细胞浸润呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.