Multispectral Imaging of Intrinsic Metabolic Fluorophores: Detection of Human Breast Cancer in Fresh Ex Vivo Specimens.

IF 1.5 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2025-01-01 DOI:10.1615/CritRevEukaryotGeneExpr.2025057627

Gary E Carver, Mark D Entwistle, Prachi N Ghule, Kyra C Lee, Donald L Weaver, Michelle M Sowden, Seth P Harlow, Jessica A Cintolo-Gonzalez, Janet L Stein, Gary S Stein

引用次数: 0

Abstract

A growing number of women develop breast cancer and require surgery. Many lumpectomies lead to follow-up procedures after the initial surgery. Advanced scanning technologies have reduced the number of second and third surgeries, but only by about 50%. This paper assesses the potential of using multispectral images of intrinsic fluorescence to detect breast cancer. Images and spectra of intrinsic fluorescence from fresh ex vivo human specimens are related to pathological analysis, and predict high sensitivity and specificity. A design for a hand-held surgical scanning tool is presented.

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内在代谢荧光团的多光谱成像：在新鲜离体标本中检测人乳腺癌。

越来越多的女性患上乳腺癌并需要手术治疗。许多肿瘤在初次手术后需要进行后续治疗。先进的扫描技术减少了第二次和第三次手术的次数，但只减少了大约50%。本文评估了使用本征荧光多光谱图像检测乳腺癌的潜力。新鲜离体人体标本的本征荧光图像和光谱与病理分析有关，预测具有高灵敏度和特异性。介绍了一种手持式手术扫描工具的设计。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.