Predictive value of systemic inflammatory response index in patients with erectile dysfunction on tadalafil unresponsive patients.

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2025-12-01 Epub Date: 2025-02-19 DOI:10.1080/13685538.2025.2467157

Resul Sobay

{"title":"Predictive value of systemic inflammatory response index in patients with erectile dysfunction on tadalafil unresponsive patients.","authors":"Resul Sobay","doi":"10.1080/13685538.2025.2467157","DOIUrl":null,"url":null,"abstract":"Background: Erectile dysfunction (ED) is a common disorder that significantly impacts quality of life, and phosphodiesterase type 5 inhibitors (PDE5is) such as tadalafil are one of the primary treatments. However, some patients remain unresponsive, necessitating further investigation.Objective: To investigate the association between systemic inflammatory response index (SIRI) and tadalafil unresponsiveness in erectile dysfunction patients.Methods: A total of 106 male patients who applied to the Andrology outpatient clinic with ED complaints between January and June 2024 were included in the study. Patients were started on daily tadalafil 5 mg therapy, and response was assessed after one month using the International Index of Erectile Function Erectile Function domain (IIEF-EF). SIRI values, calculated using neutrophil, monocyte, and lymphocyte counts, were compared between tadalafil-responsive and unresponsive groups.Results: Tadalafil unresponsiveness was observed in 48.1% of patients. Non-responders had significantly higher mean age(57.44 ± 12.52 vs. 47.22 ± 11.49, p < 0.001), BMI(27.22 ± 3.17 vs. 25.85 ± 2.92, p = 0.023), and SIRI values(1.33 ± 0.82 vs. 1.02 ± 0.40, p = 0.016) compared to responders. Multivariate analysis identified age(OR = 1,641, p = 0.001) and SIRI(OR = 2.420, p = 0.014) as independent predictors of tadalafil failure. ROC curve analysis revealed a SIRI cutoff of 1.03 (AUC = 0.617) with 69.1% sensitivity and 61.2% specificity.Conclusion: Findings suggest that systemic inflammation plays a key role in ED pathophysiology and may impair PDE5i efficacy.","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2467157"},"PeriodicalIF":2.7000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging Male","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13685538.2025.2467157","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Erectile dysfunction (ED) is a common disorder that significantly impacts quality of life, and phosphodiesterase type 5 inhibitors (PDE5is) such as tadalafil are one of the primary treatments. However, some patients remain unresponsive, necessitating further investigation.

Objective: To investigate the association between systemic inflammatory response index (SIRI) and tadalafil unresponsiveness in erectile dysfunction patients.

Methods: A total of 106 male patients who applied to the Andrology outpatient clinic with ED complaints between January and June 2024 were included in the study. Patients were started on daily tadalafil 5 mg therapy, and response was assessed after one month using the International Index of Erectile Function Erectile Function domain (IIEF-EF). SIRI values, calculated using neutrophil, monocyte, and lymphocyte counts, were compared between tadalafil-responsive and unresponsive groups.

Results: Tadalafil unresponsiveness was observed in 48.1% of patients. Non-responders had significantly higher mean age(57.44 ± 12.52 vs. 47.22 ± 11.49, p < 0.001), BMI(27.22 ± 3.17 vs. 25.85 ± 2.92, p = 0.023), and SIRI values(1.33 ± 0.82 vs. 1.02 ± 0.40, p = 0.016) compared to responders. Multivariate analysis identified age(OR = 1,641, p = 0.001) and SIRI(OR = 2.420, p = 0.014) as independent predictors of tadalafil failure. ROC curve analysis revealed a SIRI cutoff of 1.03 (AUC = 0.617) with 69.1% sensitivity and 61.2% specificity.

Conclusion: Findings suggest that systemic inflammation plays a key role in ED pathophysiology and may impair PDE5i efficacy.

查看原文本刊更多论文

勃起功能障碍患者全身炎症反应指数对他达拉非无反应患者的预测价值。

背景：勃起功能障碍（ED）是一种严重影响生活质量的常见疾病，磷酸二酯酶5型抑制剂（PDE5is）如他达拉非是主要治疗方法之一。然而，一些患者仍无反应，需要进一步调查。目的：探讨勃起功能障碍患者全身炎症反应指数（SIRI）与他达拉非无反应性的关系。方法：选取2024年1 - 6月在男科门诊就诊的106例男性ED主诉患者作为研究对象。患者开始每日他达拉非5mg治疗，一个月后使用国际勃起功能指数勃起功能域（IIEF-EF）评估疗效。使用中性粒细胞、单核细胞和淋巴细胞计数计算SIRI值，比较他达拉非反应组和无反应组之间的SIRI值。结果：48.1%的患者对他达拉非无反应。无应答者的平均年龄（57.44±12.52比47.22±11.49,p = 0.023）和SIRI值（1.33±0.82比1.02±0.40,p = 0.016）显著高于应答者。多因素分析发现，年龄（OR = 1,641, p = 0.001）和SIRI（OR = 2.420, p = 0.014）是他他非失败的独立预测因子。ROC曲线分析显示SIRI截断值为1.03 (AUC = 0.617)，敏感性为69.1%，特异性为61.2%。结论：研究结果提示全身性炎症在ED病理生理中起关键作用，并可能损害PDE5i的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.