Association of social isolation and loneliness with all-cause and cause-specific mortality among individuals with type 2 diabetes: a prospective study in UK Biobank.

IF 4.9 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Xiaoran Duan, Yujie Wei, Yahao Ge, Yacong Bo, Xiaofang Wang, Yongjian Zhu
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引用次数: 0

Abstract

Background: Previous study revealed that social isolation and loneliness are associated with incident type 2 diabetes mellitus (T2DM). However, the long-term effects of social isolation and loneliness on the population with T2DM have not been known. This study aims to evaluate the potential associations of social isolation and loneliness with all-cause and cause-specific mortality in individuals with T2DM.

Methods: The prospective cohort study included 26 549 UK adults diagnosed with T2DM at baseline. Social isolation and loneliness were evaluated through a self-reported questionnaire. Mortality data was obtained from the National Death Registration Centre.

Results: During a median follow-up of 13.3 years (IQR: 12.5-14.2 years), 5467 (20.6%) participants died from all-cause, 1953 (7.4%) from cardiovascular disease (CVD) and 1569 (5.9%) from cancer. Social isolation could increase the risks of all-cause, CVD and cancer mortality (most vs least; adjusted HR (95% CI): 1.32 (1.22-1.42), 1.44 (1.26-1.65) and 1.19 (1.05-1.34), respectively). Similarly, loneliness significantly increased the risks of all-cause, and CVD mortality (yes vs no; adjusted HR (95% CI): 1.17 (1.07-1.28) and 1.26 (1.07-1.48)). In joint analyses, as the degree of social isolation intensified, there were concomitant rises in the risks of all-cause, and CVD mortality in the no-loneliness or loneliness subgroup (adjusted HR (95% CI): 1.4 (1.21-1.61) and 1.65 (1.29-2.11)).

Conclusions: This study found that social isolation was significantly associated with the increased risks of all-cause, CVD and cancer mortality among individuals with T2DM. Loneliness was also associated with all-cause mortality and CVD mortality, but not cancer mortality. These findings highlight the importance of social isolation and loneliness management in patients with T2DM.

社会孤立和孤独与2型糖尿病患者全因和特定原因死亡率的关系:英国生物银行的一项前瞻性研究
背景:以往的研究表明,社会隔离和孤独感与2型糖尿病(T2DM)的发生有关。然而,社会隔离和孤独感对2型糖尿病患者的长期影响尚不清楚。本研究旨在评估社会隔离和孤独感与T2DM患者全因死亡率和病因特异性死亡率的潜在关联。方法:前瞻性队列研究包括26549名基线诊断为T2DM的英国成年人。社会孤立和孤独感通过自我报告问卷进行评估。死亡率数据来自国家死亡登记中心。结果:在中位随访13.3年(IQR: 12.5-14.2年)期间,5467名(20.6%)参与者死于全因,1953名(7.4%)死于心血管疾病(CVD), 1569名(5.9%)死于癌症。社会孤立可能会增加全因、心血管疾病和癌症死亡率的风险(大多数vs最小;调整后的HR (95% CI)分别为1.32(1.22-1.42)、1.44(1.26-1.65)和1.19(1.05-1.34)。同样,孤独显著增加了全因和心血管疾病死亡率的风险(是vs否;调整后的HR (95% CI): 1.17(1.07-1.28)和1.26(1.07-1.48))。在联合分析中,随着社会隔离程度的加剧,无孤独感或孤独感亚组的全因风险和心血管疾病死亡率也随之上升(校正HR (95% CI): 1.4(1.21-1.61)和1.65(1.29-2.11))。结论:本研究发现,社会隔离与T2DM患者全因、心血管疾病和癌症死亡率的风险增加显著相关。孤独也与全因死亡率和心血管疾病死亡率有关,但与癌症死亡率无关。这些发现强调了2型糖尿病患者社会隔离和孤独感管理的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Epidemiology and Community Health
Journal of Epidemiology and Community Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
11.10
自引率
0.00%
发文量
100
审稿时长
3-6 weeks
期刊介绍: The Journal of Epidemiology and Community Health is a leading international journal devoted to publication of original research and reviews covering applied, methodological and theoretical issues with emphasis on studies using multidisciplinary or integrative approaches. The journal aims to improve epidemiological knowledge and ultimately health worldwide.
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