Understanding of Thirst in Medical Science.

IF 0.9 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Yonago acta medica Pub Date : 2025-01-18 eCollection Date: 2025-02-01 DOI:10.33160/yam.2025.02.001
Takeshi Y Hiyama
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引用次数: 0

Abstract

Thirst is fundamentally considered as a physiological function developed to maintain the homeostasis of body fluids. However, we occasionally experience thirst in situations that are not necessarily related to the maintenance of bodily fluid homeostasis. Because the only method available had been to quantify the degree of thirst using psychological indices, thirst research had made little progress until very recently. To quantitatively analyze thirst, it is necessary to elucidate the nature of the brain's "thirst center," which is believed to become active in response to thirst. Textbooks of physiology often refer to the "thirst center" in the hypothalamus, which is considered to sense the osmotic pressure of body fluids. However, they did not specify the location of this center in the hypothalamus. Furthermore, the existence of the so-called "osmotic pressure sensors" has yet to be confirmed. However, recently, a series of findings have been published that delve into the true nature of the thirst center. These advancements have been achieved using several new techniques, including the real-time monitoring of neural activities related to thirst regulation within the brains of experimental animals. At least at the animal level, recent advancements in experimental techniques have made it possible to objectively quantify the intensity of thirst as a physiological response. In this review article, the history of our research is presented and latest developments in thirst research are presented.

医学对口渴的认识
口渴从根本上被认为是一种维持体液平衡的生理功能。然而,我们偶尔会在与体液平衡维持无关的情况下感到口渴。由于唯一可用的方法是使用心理指标来量化口渴的程度,直到最近,对口渴的研究才取得了一些进展。为了定量分析口渴,有必要阐明大脑“口渴中心”的性质,该中心被认为在口渴时变得活跃。生理学教科书经常提到下丘脑中的“口渴中心”,它被认为是感知体液的渗透压。然而,他们没有具体说明这个中心在下丘脑的位置。此外,所谓的“渗透压传感器”的存在还有待证实。然而,最近发表的一系列研究结果深入研究了口渴中枢的真实本质。这些进步是通过几种新技术实现的,包括对实验动物大脑中与口渴调节相关的神经活动的实时监测。至少在动物水平上,最近实验技术的进步使得客观地量化口渴的强度作为一种生理反应成为可能。在这篇综述文章中,介绍了我们的研究历史和口渴研究的最新进展。
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来源期刊
Yonago acta medica
Yonago acta medica MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.60
自引率
0.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: Yonago Acta Medica (YAM) is an electronic journal specializing in medical sciences, published by Tottori University Medical Press, 86 Nishi-cho, Yonago 683-8503, Japan. The subject areas cover the following: molecular/cell biology; biochemistry; basic medicine; clinical medicine; veterinary medicine; clinical nutrition and food sciences; medical engineering; nursing sciences; laboratory medicine; clinical psychology; medical education. Basically, contributors are limited to members of Tottori University and Tottori University Hospital. Researchers outside the above-mentioned university community may also submit papers on the recommendation of a professor, an associate professor, or a junior associate professor at this university community. Articles are classified into four categories: review articles, original articles, patient reports, and short communications.
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