Potential Efficacy of Inflammatory Response Markers for the Detection of Ovarian Cancer in Patients with Endometrioma.

IF 0.9 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Yonago acta medica Pub Date : 2025-01-23 eCollection Date: 2025-02-01 DOI:10.33160/yam.2025.02.006
Yuki Iida, Shinya Sato, Koji Yamamoto, Masayo Okawa, Kohei Hikino, Mayumi Sawada, Hiroaki Komatsu, Fuminori Taniguchi
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引用次数: 0

Abstract

Background: This study evaluated the effectiveness of preoperative inflammatory response markers in distinguishing clear cell carcinoma (CCC) and endometrioid carcinoma (EC) from ovarian endometrioma.

Methods: Patients with stage I ovarian cancer with histology CCC/EC or endometrioma who underwent surgery at our institution between 2010 and 2021 were included. Preoperative inflammatory response markers evaluated were white blood cell count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, D-dimer, neutrophil/lymphocyte ratio (NLR), platelet count/lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). The tumor markers CA125 and CA19-9 were analyzed. The median values of these markers were compared between the CCC/EC and the endometrioma groups. The areas under the curve (AUC) in Receiver Operating Characteristic analysis were compared.

Results: Fifty patients with stage I CCC/EC and 247 patients with endometrioma were included in the study. Inflammatory response markers were significantly higher in CCC/EC cases than in endometrioma cases (P < 0.01). Tumor markers demonstrated higher specificity than inflammatory response markers. The AUCs of CRP, ESR, D-dimer, NLR, and SII were significantly higher than those of CA125 and CA19-9 (P < 0.01). The values of NLR, PLR, and SII in four cases of ovarian cancer with preoperative suspected endometrioma were higher than the cut-off value.

Conclusion: Inflammatory response markers may be useful for the detection of stage I ovarian cancer. Notably, the NLR or SII, calculated using a complete blood count, appears particularly efficient. Combining tumor and inflammatory response markers may enhance diagnostic accuracy in distinguishing ovarian cancer from endometrioma.

炎症反应标记物对子宫内膜瘤患者卵巢癌检测的潜在功效
背景:本研究评估术前炎症反应标志物在区分卵巢子宫内膜异位瘤中透明细胞癌(CCC)和子宫内膜样癌(EC)的有效性。方法:纳入2010年至2021年间在我院接受手术的组织学为CCC/EC或子宫内膜异位瘤的I期卵巢癌患者。术前评估炎症反应指标为白细胞计数、c反应蛋白(CRP)、红细胞沉降率(ESR)、纤维蛋白原、d -二聚体、中性粒细胞/淋巴细胞比值(NLR)、血小板计数/淋巴细胞比值(PLR)和全身免疫炎症指数(SII)。分析肿瘤标志物CA125和CA19-9。比较CCC/EC组和子宫内膜异位瘤组这些标志物的中位数。比较了受试者工作特性分析的曲线下面积(AUC)。结果:50例I期CCC/EC患者和247例子宫内膜异位瘤患者纳入研究。炎症反应指标在CCC/EC组明显高于子宫内膜异位瘤组(P < 0.01)。肿瘤标志物比炎症反应标志物具有更高的特异性。CRP、ESR、d -二聚体、NLR、SII的auc均显著高于CA125、CA19-9 (P < 0.01)。4例术前怀疑子宫内膜异位瘤的卵巢癌患者NLR、PLR、SII值均高于临界值。结论:炎症反应标志物可用于ⅰ期卵巢癌的检测。值得注意的是,使用全血细胞计数计算的NLR或SII似乎特别有效。结合肿瘤和炎症反应标志物可提高卵巢癌和子宫内膜瘤的诊断准确性。
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来源期刊
Yonago acta medica
Yonago acta medica MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.60
自引率
0.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: Yonago Acta Medica (YAM) is an electronic journal specializing in medical sciences, published by Tottori University Medical Press, 86 Nishi-cho, Yonago 683-8503, Japan. The subject areas cover the following: molecular/cell biology; biochemistry; basic medicine; clinical medicine; veterinary medicine; clinical nutrition and food sciences; medical engineering; nursing sciences; laboratory medicine; clinical psychology; medical education. Basically, contributors are limited to members of Tottori University and Tottori University Hospital. Researchers outside the above-mentioned university community may also submit papers on the recommendation of a professor, an associate professor, or a junior associate professor at this university community. Articles are classified into four categories: review articles, original articles, patient reports, and short communications.
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