The Association Between Longer Maternal Leukocyte Telomere Length in the Immediate Postpartum Period and Preterm Birth in a Predominately Latina Cohort of Mothers.
IF 1.8 4区 医学Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Usah Dutson, Jue Lin, Laura L Jelliffe-Pawlowski, Kimberly Coleman-Phox, Larry Rand, Janet M Wojcicki
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引用次数: 0
Abstract
Objectives: We investigated the association between maternal leukocyte telomere length (LTL) in the immediate postpartum period and moderate to late preterm birth (32- < 37 weeks) among Latinas, a population at high risk for preterm birth.
Methods: Maternal LTL was measured using quantitative polymerase chain reaction at delivery in a prospective San Francisco primarily Latina birth cohort. Logistic regression models were used to investigate the association between postpartum maternal LTL and preterm birth. Maternal LTL was analyzed as a continuous predictor.
Results: Out of 194 participants, 23 (11.9%) had preterm delivery. Longer postnatal maternal LTL was associated with preterm birth (crude OR 4.68; 95% confidence interval (CI) 1.07, 20.6, p = 0.039; adjusted OR 12.8, 95% CI 1.83, 99.9, p = 0.010). Age-stratified analysis showed that being under 35 years increased the effect size of the association between maternal LTL and preterm birth (adjusted OR 32.5, 95% CI 2.58, 597, p < 0.01).
Conclusions for practice: Latina mothers with moderate to late preterm infants had longer LTL in the immediate postpartum period compared to those with term infants. This association was stronger for mothers under the age of 35 years. LTL may serve as a biomarker to better understand the pathophysiology and risk of preterm birth and could inform targeted interventions for prevention and early detection. Future studies are needed to understand physiological changes in maternal LTL from the prenatal to postnatal period in relation to birth outcomes.
目的:我们研究了产妇产后白细胞端粒长度(LTL)与中度至晚期早产之间的关系。方法:在前瞻性旧金山主要拉丁裔出生队列中,使用定量聚合酶链反应测量分娩时产妇的LTL。采用Logistic回归模型探讨产后产妇LTL与早产的关系。母体LTL作为连续预测因子进行分析。结果:194名参与者中,23名(11.9%)早产。较长的产后母亲LTL与早产相关(粗比值为4.68;95%置信区间(CI) 1.07, 20.6, p = 0.039;调整OR 12.8, 95% CI 1.83, 99.9, p = 0.010)。年龄分层分析显示,年龄在35岁以下增加了母亲LTL与早产之间关联的效应量(调整后OR为32.5,95% CI为2.58,597,p)。实践结论:与足月婴儿相比,中度至晚期早产儿的拉丁裔母亲在产后即刻的LTL更长。这种关联在35岁以下的母亲中更为明显。LTL可以作为一种生物标志物,更好地了解早产的病理生理和风险,并可以为预防和早期发现提供有针对性的干预措施。未来的研究需要了解母体LTL从产前到产后的生理变化与分娩结果的关系。
期刊介绍:
Maternal and Child Health Journal is the first exclusive forum to advance the scientific and professional knowledge base of the maternal and child health (MCH) field. This bimonthly provides peer-reviewed papers addressing the following areas of MCH practice, policy, and research: MCH epidemiology, demography, and health status assessment
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