Bacteriophage Therapy for Chronic Mastoiditis.

IF 1.9 3区 医学 Q3 CLINICAL NEUROLOGY
Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-01-22 DOI:10.1097/MAO.0000000000004417
Julia Casazza, Donald Tan, Mark Newcomer, Hitomi Sakano, Brandon Isaacson, Jacob B Hunter
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引用次数: 0

Abstract

Objective: To provide the first description of intratympanic bacteriophage therapy for chronic mastoiditis from multidrug-resistant Pseudomonas aeruginosa in the United States.

Patients: A 47-year-old woman with chronic mastoiditis in the setting of ciliary dysfunction from cystic fibrosis and immunosuppression from lung transplantation.

Interventions: Ten concurrent parenteral and intratympanic doses of two custom phages targeting P. aeruginosa followed by IV antibiotic therapy.

Main outcome measures: Resolution of infection confirmed by symptomatology, cultures, and imaging.

Results: At 5 months after phage treatment, the patient reported resolution of otorrhea, headaches, and hearing impairment. Subsequent cultures showed no growth.

Conclusions: Bacteriophages can enhance antibiotic activity in cases of drug-resistant chronic mastoiditis.

慢性乳突炎的噬菌体治疗。
目的:在美国首次报道耐多药铜绿假单胞菌引起的慢性乳突炎的鼓室内噬菌体治疗。患者:47岁女性,慢性乳突炎,睫状体功能障碍,囊性纤维化和肺移植免疫抑制。干预措施:10次同时注射两种针对铜绿假单胞菌的定制噬菌体,然后静脉注射抗生素治疗。主要观察指标:通过症状学、培养和影像学证实感染的消退。结果:在噬菌体治疗5个月后,患者报告耳漏、头痛和听力障碍的消退。随后的培养没有显示出生长。结论:噬菌体可增强耐药慢性乳突炎的抗生素活性。
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来源期刊
Otology & Neurotology
Otology & Neurotology 医学-耳鼻喉科学
CiteScore
3.80
自引率
14.30%
发文量
509
审稿时长
3-6 weeks
期刊介绍: ​​​​​Otology & Neurotology publishes original articles relating to both clinical and basic science aspects of otology, neurotology, and cranial base surgery. As the foremost journal in its field, it has become the favored place for publishing the best of new science relating to the human ear and its diseases. The broadly international character of its contributing authors, editorial board, and readership provides the Journal its decidedly global perspective.
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