Comparative models of uveitis.

IF 2.8 3区 医学 Q1 OPHTHALMOLOGY
Eye Pub Date : 2025-02-18 DOI:10.1038/s41433-025-03693-6
Olivia S Knutson, Soyoung Choi, Simon Williams, Virginia L Calder
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引用次数: 0

Abstract

Several clinical subtypes of uveitis exist yet specific immunopathogenic mechanisms involved remain unclear. Ex vivo studies are limited by lack of fresh retinal biopsies and studies have relied on aqueous humour or peripheral blood, which may not directly reflect disease. The aim of this review is to compare the various in vivo models and review their contributions to our understanding of disease processes. These models, although unable to reflect all clinical signs, have provided insight into the contribution of genes and molecules, characterisation of effector T-cells, cell trafficking into retinal tissues, the contribution of tissue-resident myeloid cells and the mechanism(s) of action of several anti-inflammatory compounds. In vivo uveitis models have provided an excellent resource with which to study the molecular and cellular processes involved. Recent refinements in models, improved imaging, and the application of omics have greatly increased the number of readouts and translational opportunities. Future approaches with in vitro models will also be discussed.

葡萄膜炎的比较模型。
葡萄膜炎存在几种临床亚型,但具体的免疫致病机制尚不清楚。由于缺乏新鲜的视网膜活组织检查,体外研究受到限制,而且研究依赖于体液或外周血,这可能不能直接反映疾病。这篇综述的目的是比较各种体内模型,并回顾它们对我们理解疾病过程的贡献。这些模型虽然不能反映所有的临床症状,但已经深入了解了基因和分子的作用、效应t细胞的特征、细胞运输到视网膜组织的作用、组织内骨髓细胞的作用以及几种抗炎化合物的作用机制。体内葡萄膜炎模型为研究所涉及的分子和细胞过程提供了极好的资源。最近模型的改进、成像的改进和组学的应用大大增加了读出的数量和转化的机会。未来的方法与体外模型也将讨论。
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来源期刊
Eye
Eye 医学-眼科学
CiteScore
6.40
自引率
5.10%
发文量
481
审稿时长
3-6 weeks
期刊介绍: Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists. Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.
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