Assessing omeprazole and flunixin meglumine co-administration in treating equine gastric ulcer syndrome in Mongolian horses.

IF 2.4 2区 农林科学 Q1 VETERINARY SCIENCES
Wenrui Guo, Zhengyi Li, Wei Mao, Xinyu Liu, Ying Yang, Jiahui Yu, Huidi Yang, Ruifeng Gao
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引用次数: 0

Abstract

Background: Flunixin meglumine (FM) is commonly used in painful conditions in horses; however, it may contribute to equine gastric ulcer syndrome (EGUS). Some veterinarians combine omeprazole (OME) and FM to reduce EGUS risk. However, the efficacy and safety of this combination in Mongolian horses with chronic lameness remain unknown.

Objectives: To investigate the changes in lameness and EGUS scores in Mongolian horses through the comparison of three treatment strategies: FM, FM + OME and placebo treated control (CON) and to assess the effects of these treatments on gastric fluid pH, serum total protein, albumin and oxidative stress markers (MPO, SOD, CAT).

Study design: In vivo experiments.

Methods: Eighteen Mongolian horses with initial American Association of Equine Practitioners lameness scores ≥3 of 5 were selected and equally divided into the placebo (CON), FM (1.1 mg/kg IV q. 24 h) and FM + OME (4 mg/kg PO q. 24 h) treatment groups in a randomised block design. During 15 days of treatment, weekly gastroscopy and physiological and biochemical tests were performed. Stomach tissues were harvested from two horses from each group for histopathological examination with haematoxylin and eosin, Masson's trichrome and periodic acid-Schiff (PAS) staining.

Results: FM (median 1.0, interquartile range 0.0-1.0; p < 0.001) and FM + OME (1.0, 1.0-1.0; p < 0.001) significantly decreased lameness scores compared with CON (3.0, 3.0-4.0). Compared with CON (EGGD: 0.0, 0.0-1.0, p < 0.001; PG1: mean 231.9 ± standard deviation 25.2 ng/mL, p < 0.001) or FM + OME (EGGD: 0.8, 1.0-1.3, p = 0.003; PG1: 207.08 ± 34.85 ng/mL, p < 0.001), FM significantly increased equine gastric glandular disease (EGGD) grade (3.0, 2.0-3.3) and pepsinogen 1 (PG1) content (372.2 ± 33.2 ng/mL, p < 0.001). Compared with CON (total protein: 70.1 ± 2.9 g/L; albumin: 37.0 ± 3.0 g/L; Gastrin-17: 482.5 ± 48.1 pg/mL), FM significantly reduced total protein (62.8 ± 2.9 g/L, p = 0.003), albumin (31.5 ± 2.3 g/L, p = 0.01) and Gastrin-17 (GT-17) content (284.6 ± 57.2 pg/mL, p < 0.001). Compared with FM (EGGD: 3.0, 2.0-3.3; pH: 2.4 ± 0.3), FM + OME significantly decreased the EGGD grade (0.8, 1.0-1.3; p = 0.003) and significantly increased gastric fluid pH (7.4 ± 0.2; p < 0.001). FM + OME (207.1 ± 34.9 ng/mL) significantly decreased PG1 content compared with FM (372.24 ± 33.25 ng/mL; p < 0.001). Histopathology revealed that 15 days of FM treatment led to gastric lesions in horses, which were mitigated by combining with OME.

Main limitations: Individual differences among horses were large, but the sample size was small and sampling was infrequent.

Conclusions: Compared with FM alone, use of FM + OME did not impact the reduction in lameness scores with therapy, but reduced the occurrence of EGGD in Mongolian horses. When used to manage chronic lameness, FM + OME might protect against FM-induced EGGD by increasing the gastric pH and decreasing serum PG1 content.

评价奥美拉唑与氟尼新大明联合用药治疗蒙古马胃溃疡综合征的疗效。
背景:氟尼辛甲胺(FM)常用于马的疼痛状态;然而,它可能导致马胃溃疡综合征(EGUS)。一些兽医联合奥美拉唑(OME)和FM来降低EGUS的风险。然而,这种组合在患有慢性跛行的蒙古马中的有效性和安全性仍然未知。目的:通过FM、FM + OME和安慰剂治疗对照(CON)三种治疗策略的比较,探讨蒙古马跛行和EGUS评分的变化,并评估这些治疗对胃液pH、血清总蛋白、白蛋白和氧化应激标志物(MPO、SOD、CAT)的影响。研究设计:体内实验。方法:选择18匹美国马术协会跛行评分≥3分的蒙古马,采用随机区组设计,平均分为安慰剂(CON)、FM (1.1 mg/kg IV每24 h)和FM + OME (4 mg/kg PO每24 h)治疗组。在15天的治疗期间,每周进行胃镜检查和生理生化检查。每组取2匹马的胃组织进行组织病理学检查,采用苏木精和伊红、马松三色和周期性酸希夫(PAS)染色。结果:FM(中位数1.0,四分位数范围0.0-1.0;p主要局限性:马的个体差异大,但样本量小,采样频率低。结论:与单独使用FM相比,使用FM + OME不影响治疗中跛行评分的降低,但减少了蒙古马EGGD的发生。当用于治疗慢性跛行时,FM + OME可能通过增加胃pH值和降低血清PG1含量来防止FM诱导的EGGD。
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来源期刊
Equine Veterinary Journal
Equine Veterinary Journal 农林科学-兽医学
CiteScore
5.10
自引率
13.60%
发文量
161
审稿时长
6-16 weeks
期刊介绍: Equine Veterinary Journal publishes evidence to improve clinical practice or expand scientific knowledge underpinning equine veterinary medicine. This unrivalled international scientific journal is published 6 times per year, containing peer-reviewed articles with original and potentially important findings. Contributions are received from sources worldwide.
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