{"title":"Predictive Value of Lp-PLA2 Combined with Leukocyte-Derived Markers for Heart Failure After Acute Myocardial Infarction.","authors":"Guohua Xia, Shengxing Tang","doi":"10.7754/Clin.Lab.2024.240735","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>We aimed to evaluate the value of lipoprotein-associated phospholipase A2 (Lp-PLA2) in the serum plus leukocyte-derived markers such as platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) for predicting heart failure (HF) after acute myocardial infarction (AMI).</p><p><strong>Methods: </strong>A total of 80 AMI patients (case group) hospitalized between June 2019 and July 2022 and 80 healthy subjects (healthy group) were selected. An HF group and a non-HF group were established for the case group. The general data, serum Lp-PLA2 concentration, PLR, and NLR were compared between the two subgroups. Analysis of the risk factors for HF in AMI patients was performed.</p><p><strong>Results: </strong>The case group, compared with the healthy group, had higher serum Lp-PLA2 concentration, PLR, and NLR (p < 0.05). HF occurred in 10 cases (12.50%) in the case group. In comparison to the non-HF group, increases of serum Lp-PLA2 concentration, PLR, and NLR were detected in the HF group (p < 0.05). Elevated se-rum Lp-PLA2 concentration, PLR, and NLR served as risk factors for HF in AMI patients (OR > 1, p < 0.05). NLR, PLR, serum Lp-PLA2, and combination of the three had the areas under the curves of 0.734, 0.731, 0.719, and 0.910, respectively, in predicting HF in AMI patients.</p><p><strong>Conclusions: </strong>NLR, PLR, and serum Lp-PLA2 concentration were elevated in AMI patients, that were associated with HF. Combined determination of NLR, PLR, and serum Lp-PLA2 can effectively predict the risk of HF in AMI patients.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2024.240735","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: We aimed to evaluate the value of lipoprotein-associated phospholipase A2 (Lp-PLA2) in the serum plus leukocyte-derived markers such as platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) for predicting heart failure (HF) after acute myocardial infarction (AMI).
Methods: A total of 80 AMI patients (case group) hospitalized between June 2019 and July 2022 and 80 healthy subjects (healthy group) were selected. An HF group and a non-HF group were established for the case group. The general data, serum Lp-PLA2 concentration, PLR, and NLR were compared between the two subgroups. Analysis of the risk factors for HF in AMI patients was performed.
Results: The case group, compared with the healthy group, had higher serum Lp-PLA2 concentration, PLR, and NLR (p < 0.05). HF occurred in 10 cases (12.50%) in the case group. In comparison to the non-HF group, increases of serum Lp-PLA2 concentration, PLR, and NLR were detected in the HF group (p < 0.05). Elevated se-rum Lp-PLA2 concentration, PLR, and NLR served as risk factors for HF in AMI patients (OR > 1, p < 0.05). NLR, PLR, serum Lp-PLA2, and combination of the three had the areas under the curves of 0.734, 0.731, 0.719, and 0.910, respectively, in predicting HF in AMI patients.
Conclusions: NLR, PLR, and serum Lp-PLA2 concentration were elevated in AMI patients, that were associated with HF. Combined determination of NLR, PLR, and serum Lp-PLA2 can effectively predict the risk of HF in AMI patients.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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