Emerging agents targeting triglycerides.

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yash Prakash, Deepak L Bhatt, Waqas A Malick
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引用次数: 0

Abstract

Purpose of review: Hypertriglyceridemia (HTG), which arises from defects in triglyceride-rich lipoprotein (TRL) metabolism, is associated with increased morbidity and mortality from pancreatitis and atherosclerotic cardiovascular disease. Traditional therapies, including fibrates and omega-3 fatty acids, have shown limited efficacy in controlling triglyceride (TG) levels and cardiovascular risk. This review explores the role of emerging therapies that target TG and TRL metabolism via novel biochemical pathways.

Recent findings: Apolipoprotein C-III inhibitors appear most effective for patients with variants of severe HTG, particularly multifactorial and familial chylomicronemia syndromes, by enhancing TRL metabolism through both lipoprotein lipase-dependent and independent mechanisms. Angiopoeitin-like proteins 3 and 4 inhibitors appear most useful for mixed hyperlipidemia, with favorable effects across the entire spectrum of apoB-containing atherogenic lipoproteins. For patients with HTG and concomitant complications of insulin resistance, including metabolic associated steatotic liver disease and type 2 diabetes mellitus, fibroblast growth factor-21 analogs may provide significant benefit.

Summary: HTG is a diverse condition. Apolipoprotein C-III inhibitors, angiopoeitin-like proteins 3 and 4 inhibitors, and fibroblast growth factor-21 analogs represent significant advancements in the treatment of HTG, offering new hope for effectively managing this condition across its full spectrum of disease.

针对甘油三酯的新兴药物。
回顾目的:高甘油三酯血症(HTG)是由富含甘油三酯的脂蛋白(TRL)代谢缺陷引起的,与胰腺炎和动脉粥样硬化性心血管疾病的发病率和死亡率增加有关。传统的治疗方法,包括贝特酸盐和omega-3脂肪酸,在控制甘油三酯(TG)水平和心血管风险方面的效果有限。这篇综述探讨了通过新的生化途径靶向TG和TRL代谢的新兴疗法的作用。最近的研究发现:载脂蛋白C-III抑制剂似乎通过脂蛋白脂酶依赖和独立机制增强TRL代谢,对严重HTG变体患者,特别是多因子和家族性乳糜微粒血症综合征最有效。血管生成素样蛋白3和4抑制剂似乎对混合性高脂血症最有用,对所有含载脂蛋白的致动脉粥样硬化脂蛋白都有良好的效果。对于HTG和胰岛素抵抗并发症患者,包括代谢相关脂肪变性肝病和2型糖尿病,成纤维细胞生长因子-21类似物可能提供显著的益处。摘要:HTG是一种多样的疾病。载脂蛋白C-III抑制剂、血管生成素样蛋白3和4抑制剂以及成纤维细胞生长因子-21类似物代表了HTG治疗的重大进展,为有效管理HTG的全谱疾病提供了新的希望。
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来源期刊
Current opinion in lipidology
Current opinion in lipidology 医学-内分泌学与代谢
CiteScore
6.70
自引率
4.50%
发文量
64
审稿时长
6-12 weeks
期刊介绍: With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.
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