Lineage Switch from Acute Lymphoblastic Leukemia to Acute Myeloid Leukemia with PDGFRB Mutation after Allogeneic Stem Cell Transplantation.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-02-01 DOI:10.7754/Clin.Lab.2024.240833

Hongjuan Yu, Xuefen Qi, Jifei Zhang, Lingrong He

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引用次数: 0

Abstract

Background: The goal was to investigate the clinical characteristics of acute T-lymphoblastic leukemia (T-ALL) transforming into acute myeloid leukemia (AML) and to provide a basis for improved clinical diagnosis and treatment of this condition.

Methods: A retrospective analysis was performed on the clinical data and treatment process of a patient with T-ALL who transitioned to AML after undergoing allogeneic hematopoietic stem cell transplantation. Relevant literature was also reviewed.

Results: The patient, a 24-year-old female, initially presented with fatigue. A comprehensive examination confirmed the diagnosis of T-ALL. Following induction chemotherapy, the patient achieved complete remission (CR) as determined by hematologic and cytogenetic assessments. The patient subsequently underwent allogeneic hema-topoietic stem cell transplantation from a sibling donor. Six months post-transplantation, bone marrow cytology indicated a relapse, with morphology and immunophenotype consistent with AML. The patient is currently in the terminal stage of a malignant tumor, with a very poor prognosis.

Conclusions: Lineage switching following acute leukemia relapse is associated with a poor prognosis, necessitating treatment adjustments based on the post-relapse phenotype. Clinically, for recurrent leukemia, comprehensive evaluations-including leukemia immunophenotyping, gene mutation analysis, and cytogenetic and molecular biological examinations-are essential to better guide treatment and assess prognosis.

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同种异体干细胞移植后PDGFRB突变的急性淋巴母细胞白血病向急性髓系白血病的谱系转换

背景：目的探讨急性t淋巴细胞白血病（T-ALL）转化为急性髓系白血病（AML）的临床特点，为改善该病的临床诊断和治疗提供依据。方法：回顾性分析1例T-ALL患者接受异基因造血干细胞移植后转变为AML的临床资料和治疗过程。并对相关文献进行了综述。结果：患者，24岁女性，最初表现为疲劳。综合检查证实了T-ALL的诊断。诱导化疗后，患者通过血液学和细胞遗传学评估达到完全缓解（CR）。患者随后接受了来自兄弟姐妹供体的同种异体造血干细胞移植。移植后6个月，骨髓细胞学显示复发，形态学和免疫表型与AML一致。患者目前处于恶性肿瘤晚期，预后很差。结论：急性白血病复发后的谱系转换与预后不良相关，需要根据复发后表型调整治疗。临床上，对于复发性白血病，综合评价——包括白血病免疫表型、基因突变分析、细胞遗传学和分子生物学检查——对于更好地指导治疗和评估预后至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.