Clinical Observation and Analysis of Transient Postoperative CA-125 Elevation in a Patient with Sigmoid Colon Adenocarcinoma.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-02-01 DOI:10.7754/Clin.Lab.2024.240750

Hao Huang, Junqi Huang, Wencheng Huang, Siqi Yang, Yifeng Tao

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引用次数: 0

Abstract

Background: Carbohydrate antigen 125 (CA-125) is commonly utilized as a tumor marker for ovarian cancer. However, CA-125 is also observed to be elevated in other malignancies such as lung cancer, liver cancer, pancreatic cancer, and thyroid cancer. The factors leading to elevated CA-125 levels and their implications are not entirely clear. Accumulation of case reports associated with elevated CA-125 will be instrumental in advancing research in this area.

Methods and results: Here, we report a case involving a 45-year-old female patient diagnosed with Sigmoid Colon Adenocarcinoma. Laparoscopic pro-surgery CA-125 levels were 13.3 U/mL (reference range: < 35 U/mL), 12 days post-surgery CA-125 levels spiked to 132.3 U/mL, one month later CA-125 levels decreased to 73.5 U/mL, and three months later they returned to normal levels. Over a five-year follow-up period, there was no evidence of tumor recurrence or metastasis.

Conclusions: Laparoscopic surgery induced a secondary elevation in CA-125 levels. The preoperative CA-125 level is more valuable for reference.

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.