{"title":"A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) Mimicking Acute Promyelocytic Leukemia.","authors":"Tianting Ma, Han Zhang, Qingyun Song","doi":"10.7754/Clin.Lab.2024.240839","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Acute myeloid leukemia (AML) with the t(8;21)(q22;q22) mutation, which produces the AML1/ETO fusion gene on chromosome 8q22, is a specific subtype of AML categorized as AML t(8;21) in the WHO classification and AML-M2 in the FAB classification. This subtype is typically linked to a positive prognosis, although variant additional chromosomal abnormalities are often observed.</p><p><strong>Methods: </strong>We report a rare case of this category with unusual karyotype and morphologic characteristic mimick-ing APL.</p><p><strong>Results: </strong>A diagnosis of acute myeloid leukemia (AML-M2) was made through comprehensive diagnostics.</p><p><strong>Conclusions: </strong>Recognition of the morphological variation is helpful in diagnosis. In addition, further research is needed to better understand the molecular mechanisms underlying unusual rearrangements and their clinical significance.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2024.240839","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Acute myeloid leukemia (AML) with the t(8;21)(q22;q22) mutation, which produces the AML1/ETO fusion gene on chromosome 8q22, is a specific subtype of AML categorized as AML t(8;21) in the WHO classification and AML-M2 in the FAB classification. This subtype is typically linked to a positive prognosis, although variant additional chromosomal abnormalities are often observed.
Methods: We report a rare case of this category with unusual karyotype and morphologic characteristic mimick-ing APL.
Results: A diagnosis of acute myeloid leukemia (AML-M2) was made through comprehensive diagnostics.
Conclusions: Recognition of the morphological variation is helpful in diagnosis. In addition, further research is needed to better understand the molecular mechanisms underlying unusual rearrangements and their clinical significance.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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