{"title":"A Case of ANCA-Associated Vasculitis with Positive PR3 and MPO Antibodies.","authors":"Hongkun Xu, Kejie Xie","doi":"10.7754/Clin.Lab.2024.240917","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases including granulomatous polyvasculitis (GPA), microscopic polyvasculitis (MPA), and eosinophilic granulomatous polyvasculitis (EGPA). The main antigens ANCA targets are protease 3 (PR3) and myeloperoxidase (MPO). PR3-ANCA is mainly related to GPA, while MPO-ANCA is related to MPA. The presence of these antibodies is critical to the diagnosis of AAV.</p><p><strong>Methods: </strong>A case of ANCA-associated vasculitis with PR3 and MPO antibody positive due to PTU was reported.</p><p><strong>Results: </strong>After the patients stopped PTU, PR3 antibody gradually decreased to negative, MPO antibody was relatively stable, and the fluorescent karyotype was p-ANCA. The positive PR3 antibody in this patient was considered to be related to PTU.</p><p><strong>Conclusion: </strong>ANCA, anti-PR3 antibody, and anti-MPO antibody are closely related to systemic vasculitis and are affected by many factors. Abnormal results in clinical work should be reviewed immediately and communicated with clinicians to avoid adverse consequences.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2024.240917","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases including granulomatous polyvasculitis (GPA), microscopic polyvasculitis (MPA), and eosinophilic granulomatous polyvasculitis (EGPA). The main antigens ANCA targets are protease 3 (PR3) and myeloperoxidase (MPO). PR3-ANCA is mainly related to GPA, while MPO-ANCA is related to MPA. The presence of these antibodies is critical to the diagnosis of AAV.
Methods: A case of ANCA-associated vasculitis with PR3 and MPO antibody positive due to PTU was reported.
Results: After the patients stopped PTU, PR3 antibody gradually decreased to negative, MPO antibody was relatively stable, and the fluorescent karyotype was p-ANCA. The positive PR3 antibody in this patient was considered to be related to PTU.
Conclusion: ANCA, anti-PR3 antibody, and anti-MPO antibody are closely related to systemic vasculitis and are affected by many factors. Abnormal results in clinical work should be reviewed immediately and communicated with clinicians to avoid adverse consequences.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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