Correlation of Urine Protein/Creatinine Ratio in Late Pregnancy with Pregnancy Outcome in Patients with Preeclampsia Combined with Hyponatremia.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-02-01 DOI:10.7754/Clin.Lab.2024.240723

Ping Zhu, Jian P Wei, Xiao Y Liu, Ren Y Huang, Ping Liu, Min Zeng, Jun Y Li

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引用次数: 0

Abstract

Background: This study aimed to analyze the correlation of urine protein/creatinine ratio (UPCR) in late pregnancy with pregnancy outcomes in patients with preeclampsia (PE) combined with hyponatremia.

Methods: The data of 288 PE patients were collected and compiled for retrospective analysis. The patients were divided into two groups: observation group (52 cases, complicated with hyponatremia) and control group (236 cases, not complicated with hyponatremia). The general conditions, clinical data, and the adverse maternal and infant outcomes were statistically analyzed in both groups. Risk factors were analyzed using logistic regression, and the predictive efficacy was assessed using the ROC curves.

Results: Comparing the general data of the two groups, the differences were not statistically significant (all p > 0.05). Multifactorial analysis showed that uric acid (OR = 0.001, p = 0.010) and 24-hour urinary protein (OR = 2.654, p = 0.001) were the independent risk factors for hyponatremia in PE. In the observation group, placental abruption (9.6%, p = 0.015), hepatic and renal impairment (38.6%, p < 0.001), pleural effusion (30.7%, p = 0.001), fetal growth restriction (50.0%, p = 0.001), fundus lesions (7.6%, p = 0.012), HELLP syndrome (7.7%, p = 0.017), mild neonatal asphyxia (17.3%, p = 0.025), severe asphyxia (3.8%, p = 0.046), metabolic acidosis (9.6%, p = 0.001), intrauterine infection (5.7%, p = 0.004), and neonatal hospitalization exceeding 20 days (30.7%, p < 0.001) occurred in a higher percentage than in the control group. There was no significant difference in postpartum hemorrhage, eclampsia, respiratory distress syndrome, abortion, or neonatal death (all p > 0.05).

Conclusions: The UPCR in late pregnancy is an independent risk factor for hyponatremia in PE. Patients with PE combined with hyponatremia are at high risk of adverse maternal and infant outcomes.

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.