Two Cases of Pseudoelevation of Plasma Thrombin Time Levels.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-02-01 DOI:10.7754/Clin.Lab.2024.240921

Jianfei Yan, Yijun Zhang

{"title":"Two Cases of Pseudoelevation of Plasma Thrombin Time Levels.","authors":"Jianfei Yan, Yijun Zhang","doi":"10.7754/Clin.Lab.2024.240921","DOIUrl":null,"url":null,"abstract":"Background: Thrombin is a protein involved in the clotting process and binds to free fibrinogen turning it into insoluble fibrin, causing blood to clot. Thrombin time (TT) is a test for the conversion of fibrinogen to fibrin on a common pathway and a screening test for the ability of a subject's plasma to convert fibrinogen to fibrin.Methods: We reported two cases of abnormal extension of TT due to different reasons. We used magnetic bead method to detect thrombin time and used time unit sec to represent TT detection data.Results: In the two cases, we found the TT results of patients taking dabigatran are abnormally high, and normal plasma contaminated with heparin can also cause abnormally high TT results.Conclusions: The influence of heparin on TT was the greatest, followed by activated prothrombin time (APTT), but the influence on prothrombin time (PT) and fibrinogen (FIB) was not obvious. TT is highly sensitive to dabigatran in blood, so TT is not suitable for monitoring dabigatran. The normal value of TT can be used to confirm whether dabigatran has drug residues. In addition, idarucizumab can be used to reverse the anticoagulant activity of dabigatran when dabigatran causes life-threatening bleeding or other high-risk bleeding surgeries.","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2024.240921","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Thrombin is a protein involved in the clotting process and binds to free fibrinogen turning it into insoluble fibrin, causing blood to clot. Thrombin time (TT) is a test for the conversion of fibrinogen to fibrin on a common pathway and a screening test for the ability of a subject's plasma to convert fibrinogen to fibrin.

Methods: We reported two cases of abnormal extension of TT due to different reasons. We used magnetic bead method to detect thrombin time and used time unit sec to represent TT detection data.

Results: In the two cases, we found the TT results of patients taking dabigatran are abnormally high, and normal plasma contaminated with heparin can also cause abnormally high TT results.

Conclusions: The influence of heparin on TT was the greatest, followed by activated prothrombin time (APTT), but the influence on prothrombin time (PT) and fibrinogen (FIB) was not obvious. TT is highly sensitive to dabigatran in blood, so TT is not suitable for monitoring dabigatran. The normal value of TT can be used to confirm whether dabigatran has drug residues. In addition, idarucizumab can be used to reverse the anticoagulant activity of dabigatran when dabigatran causes life-threatening bleeding or other high-risk bleeding surgeries.

查看原文本刊更多论文

两例血浆凝血酶原时间水平假性升高病例

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.