Age-related differences in staging, treatment and net survival in relation to frailty in adults with colon cancer in England: an analysis of the COloRECTal cancer data repository (CORECT-R) resource.

IF 6 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Sophie Pilleron, Rebecca J Birch, John Taylor, Shane O'Hanlon, Eva J A Morris
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引用次数: 0

Abstract

Objective: To describe the distribution of disease stages, receipt of major surgery, 1-year net survival (NS) and 1-year conditional NS in relation to age and frailty in adults aged ≥50 diagnosed with colon cancer in England.

Methods: We obtained data on adults aged 50-99 diagnosed with colon cancer between 2014 and 2019, followed up through December 2021, from the national population-based COloRECTal cancer Repository. Frailty was assessed using the Secondary Care Administrative Records Frailty (SCARF) index categorised into fit, mild, moderate and severe frailty. Data on major resection were obtained through linkage with Hospital Episode Statistics dataset. Major resection rates were calculated in adults with stage I-III cancer. Descriptive statistics were used as appropriate. One-year NS from cancer diagnosis and 1-year conditional NS were estimated using the Pohar-Perme estimator.

Results: Out of 130 360 individuals (48% females-50% over 75), 48.9% were fit, ranging from 69% in the 50-64 age group to 31% in the 85-99 age group. Over 80% of adults with stage I-III cancer underwent a major resection. This percentage was 58% amongst fit adults aged over 85. One-year NS decreased as age increased across all frailty levels. Differences in NS between the 50-64 age group and the 85-99 age group were reduced in adults who survived beyond 1 year from diagnosis except for severely frail adults.

Conclusion: This population-based study shows that a non-negligible proportion of older adults diagnosed with colon cancer and deemed 'fit' through the SCARF did not receive surgery that may impact their survival.

英国成年结肠癌患者与衰弱相关的分期、治疗和净生存期的年龄相关差异:结直肠癌数据存储库(correct -r)资源的分析
目的:描述英国年龄≥50岁诊断为结肠癌的成年人的疾病分期、接受大手术、1年净生存期(NS)和1年有条件NS与年龄和虚弱相关的分布。方法:我们从以人群为基础的国家结直肠癌知识库中获取了2014年至2019年期间诊断为结肠癌的50-99岁成年人的数据,并随访至2021年12月。使用二级保健行政记录虚弱(SCARF)指数评估虚弱,分为适合、轻度、中度和严重虚弱。主要切除的数据通过与医院事件统计数据集的联系获得。计算成人I-III期肿瘤的主要切除率。酌情使用描述性统计。使用Pohar-Perme估计器估计癌症诊断后的1年NS和1年条件NS。结果:在130 360个个体中(女性48%,75岁以上50%),48.9%的个体适合,50-64岁年龄组的比例为69%,85-99岁年龄组的比例为31%。超过80%的成人I-III期癌症患者接受了大切除手术。在85岁以上的健康成年人中,这一比例为58%。1年NS随着年龄的增长而下降。除严重虚弱的成年人外,50-64岁年龄组和85-99岁年龄组的NS差异在诊断后存活超过1年的成年人中减小。结论:这项以人群为基础的研究表明,被诊断为结肠癌的老年人中,有不可忽略的比例没有接受可能影响其生存的手术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Age and ageing
Age and ageing 医学-老年医学
CiteScore
9.20
自引率
6.00%
发文量
796
审稿时长
4-8 weeks
期刊介绍: Age and Ageing is an international journal publishing refereed original articles and commissioned reviews on geriatric medicine and gerontology. Its range includes research on ageing and clinical, epidemiological, and psychological aspects of later life.
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