O₂-microbubble of iron-porphyrin conjugated polyaspartamide for molecular ultrasound contrast effect.

IF 2 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology Letters Pub Date : 2025-02-19 DOI:10.1007/s10529-025-03571-x

Yoon Na Cho, Jun Woo Lim, Seung Joo Oh, Sa Ra Han, Sungwoo Cho, Jimin Jeong, Byoung Hee Han, Jae Hyun Jeong

引用次数: 0

Abstract

Objective: This study aimed to prepare oxygen-microbubbles incorporating ferrous porphyrin to emulate the oxygen-capturing ability of hemoglobin porphyrin in red blood cells.

Results: We synthesized poly(2-hydroxyethyl aspartamide) (PHEA) grafted with ferrous porphyrins (Iron-P-PHEA) and created microbubbles using 1,2-dipalmitoyl-sn-glycero-3-phosphocholine. These microbubbles trapped oxygen and retained it over a 2 h period. The O₂-microbubbles demonstrated an enhanced photoacoustic effect as an ultrasound contrast agent, as confirmed by Doppler ultrasound testing.

Conclusions: The innovative strategy for O₂-microbubble preparation enhances the efficiency of targeted delivery in molecular optical and ultrasound imaging.

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o2微泡铁卟啉偶联聚阿斯巴胺的分子超声造影剂效果。

目的：制备含铁卟啉氧微泡，模拟血红蛋白卟啉在红细胞中的捕氧能力。结果：合成了含铁卟啉（铁-p -PHEA）接枝的聚（2-羟乙基天冬酰胺）（PHEA），并用1,2-双棕榈酰-sn-甘油-3-磷酸胆碱制备了微泡。这些微泡捕获了氧气，并将其保留了2小时。多普勒超声检测证实，o2微泡作为超声造影剂具有增强的光声效应。结论：创新的o2微泡制备策略提高了分子光学和超声成像的靶向递送效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology Letters 工程技术-生物工程与应用微生物

CiteScore

5.90

自引率

3.70%

发文量

108

审稿时长

1.2 months

期刊介绍： Biotechnology Letters is the world’s leading rapid-publication primary journal dedicated to biotechnology as a whole – that is to topics relating to actual or potential applications of biological reactions affected by microbial, plant or animal cells and biocatalysts derived from them. All relevant aspects of molecular biology, genetics and cell biochemistry, of process and reactor design, of pre- and post-treatment steps, and of manufacturing or service operations are therefore included. Contributions from industrial and academic laboratories are equally welcome. We also welcome contributions covering biotechnological aspects of regenerative medicine and biomaterials and also cancer biotechnology. Criteria for the acceptance of papers relate to our aim of publishing useful and informative results that will be of value to other workers in related fields. The emphasis is very much on novelty and immediacy in order to justify rapid publication of authors’ results. It should be noted, however, that we do not normally publish papers (but this is not absolute) that deal with unidentified consortia of microorganisms (e.g. as in activated sludge) as these results may not be easily reproducible in other laboratories. Papers describing the isolation and identification of microorganisms are not regarded as appropriate but such information can be appended as supporting information to a paper. Papers dealing with simple process development are usually considered to lack sufficient novelty or interest to warrant publication.

O2-microbubble of iron-porphyrin conjugated polyaspartamide for molecular ultrasound contrast effect.

Abstract

O₂-microbubble of iron-porphyrin conjugated polyaspartamide for molecular ultrasound contrast effect.