Initial experience of magnification tomosynthesis in depiction of suspected microcalcifications: prospective reading study of a novel reconstruction algorithm prototype.
IF 1.1 4区 医学Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
{"title":"Initial experience of magnification tomosynthesis in depiction of suspected microcalcifications: prospective reading study of a novel reconstruction algorithm prototype.","authors":"Kirill Arlan, Tuomo J Meretoja, Katja Hukkinen","doi":"10.1177/02841851251317633","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Digital breast tomosynthesis (DBT) has several limitations with respect to microcalcification depiction. The quality of DBT images may be improved by modifying technical parameters; however, the amount of raw data and postprocessing computational time is unacceptably huge. Therefore, once detected it still seems necessary to take additional spot images to characterize microcalcifications. Additional imaging increases cumulative dose. Radiation risks and protection are raising issues nowadays.</p><p><strong>Purpose: </strong>To compare image quality of magnification tomosynthesis (t-spot) and synthetic spot magnification (s-spot) to conventional spot images in characterization of microcalcifications.</p><p><strong>Material and methods: </strong>This prospective single institute reading study includes 45 patients with suspected microcalcifications initially found on mammography and referred to vacuum-assisted biopsy. Conventional spot and DBT were performed. Acquired DBT data were used to reconstruct t- and s-spots. All images were reviewed by four breast radiologists in two sessions. The morphology (BI-RADS) and extent of microcalcifications were recorded. Clinical performance was evaluated using area under the receiver operating characteristic curves (AUC) for BI-RADS and Bland-Altman plots for the maximum extent of microcalcifications.</p><p><strong>Results: </strong>All four readers preferred t-spot to s-spot. The overall AUC for t-spot was 0.67 and for spot 0.69 with a difference lower than a non-inferiority margin (delta = 0.012, 95% confidence interval [CI] = -0.067-0.09, <i>P</i> = 0.772). Three readers underestimate the extent of microcalcifications on t-spots for both benign and malignant cases (<i>P</i> < 0.05). The discordance becomes more evident with the increasing extent of the lesion.</p><p><strong>Conclusion: </strong>The performance of conventional and reconstructed spots was similar but reader-dependent and inconclusive.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851251317633"},"PeriodicalIF":1.1000,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta radiologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/02841851251317633","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Digital breast tomosynthesis (DBT) has several limitations with respect to microcalcification depiction. The quality of DBT images may be improved by modifying technical parameters; however, the amount of raw data and postprocessing computational time is unacceptably huge. Therefore, once detected it still seems necessary to take additional spot images to characterize microcalcifications. Additional imaging increases cumulative dose. Radiation risks and protection are raising issues nowadays.
Purpose: To compare image quality of magnification tomosynthesis (t-spot) and synthetic spot magnification (s-spot) to conventional spot images in characterization of microcalcifications.
Material and methods: This prospective single institute reading study includes 45 patients with suspected microcalcifications initially found on mammography and referred to vacuum-assisted biopsy. Conventional spot and DBT were performed. Acquired DBT data were used to reconstruct t- and s-spots. All images were reviewed by four breast radiologists in two sessions. The morphology (BI-RADS) and extent of microcalcifications were recorded. Clinical performance was evaluated using area under the receiver operating characteristic curves (AUC) for BI-RADS and Bland-Altman plots for the maximum extent of microcalcifications.
Results: All four readers preferred t-spot to s-spot. The overall AUC for t-spot was 0.67 and for spot 0.69 with a difference lower than a non-inferiority margin (delta = 0.012, 95% confidence interval [CI] = -0.067-0.09, P = 0.772). Three readers underestimate the extent of microcalcifications on t-spots for both benign and malignant cases (P < 0.05). The discordance becomes more evident with the increasing extent of the lesion.
Conclusion: The performance of conventional and reconstructed spots was similar but reader-dependent and inconclusive.
期刊介绍：
Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
