Carbonohydrazonoyl dicyanide-linked indole carboxamides as a new scaffold for transmembrane H+/Cl- transport.

Abstract

Herein, we introduced a series of carbonohydrazonoyl dicyanide-linked indole carboxamide 1a-1c transporters. Detailed mechanistic insight into the transport manifested that superior transporter 1a facilitates the movement of Cl^- and H⁺/Cl^- in a non-specific manner via the carrier mode. Geometrical optimization with the [1a + Cl^-] complex provided an understanding of the Cl^- ion binding process with the receptor 1a.