Prenatal Opioid Use Disorder and the Risk of Congenital Anomalies in Offspring: A Population-Based Study

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2025-02-20 DOI:10.1002/bdr2.2456

Kaylee Ramage, Jennifer Yee, Sebastian Srugo, Julian Little, Shiliang Liu

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引用次数: 0

Abstract

Objective

To examine whether prenatal opioid use disorder (OUD) diagnosis is associated with the risk of congenital anomalies (CAs) in offspring.

Methods

We conducted a population-based study of mother–newborn dyads comprising.

4143 761 births delivered in Canada from 2006 to 2021. We used robust Poisson regression to examine the association between prenatal OUD diagnosis and risk of non-chromosomal CAs, adjusted for maternal age, parity, multiple gestation, co-morbidities (including mental health disorders, chronic illnesses and other substance use disorders), and infant sex.

Results

We identified a total of 21, 638 births to persons who were diagnosed with prenatal OUD and 65, 992 (159.3 per 10,000) newborns with CAs. The overall risk of CAs was 2.3 times higher in infants born to birthing persons with a diagnosis of OUD (95% CI 2.2, 2.5). Compared to those without OUD diagnoses, births to persons with a diagnosis of OUD had a higher risk of specific types of congenital microcephaly (aRR 5.2, 95% CI 4.1, 6.6), cleft palate (RR 4.8, 95% CI 3.7, 6.1), pulmonary valve atresia with intact ventricular septum (aRR 2.7, 95% CI 1.1, 6.7), and atrial septal defect (aRR 3.1, 95% CI 2.8, 3.5), among others. In particular, infants born to those with an OUD diagnosis had a 1.8 (95% CI 1.4, 2.3)-fold increased risk of having severe congenital heart disease.

Conclusion

Our findings suggest an association between prenatal OUD diagnosis and certain CAs in the offspring. Future research is necessary to better understand the role of socio-demographic factors on these associations.

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产前阿片类药物使用障碍和后代先天性异常的风险：一项基于人群的研究

目的探讨产前阿片类药物使用障碍（OUD）诊断是否与子代先天性异常（CAs）风险相关。方法我们进行了一项以人群为基础的研究。从2006年到2021年，加拿大出生了4143,761人。我们使用稳健泊松回归来检验产前OUD诊断与非染色体ca风险之间的关系，调整了产妇年龄、胎次、多胎、合共病（包括精神健康障碍、慢性疾病和其他物质使用障碍）和婴儿性别。结果共发现21,638名新生儿被诊断为产前OUD， 65,992名（每10,000人中有159.3名）新生儿患有CAs。诊断为OUD的产妇所生的婴儿发生CAs的总风险高出2.3倍（95% CI 2.2, 2.5）。与没有诊断出OUD的人相比，诊断出OUD的人出生时患有特定类型先天性小头畸形（相对危险度为5.2,95% CI为4.1,6.6）、腭裂（相对危险度为4.8,95% CI为3.7,6.1）、完整室间隔肺动脉瓣闭锁（相对危险度为2.7,95% CI为1.1,6.7）和房间隔缺损（相对危险度为3.1,95% CI为2.8,3.5）等的风险更高。特别是，诊断为OUD的婴儿患严重先天性心脏病的风险增加了1.8倍（95% CI 1.4, 2.3）。结论本研究结果提示产前OUD诊断与后代某些ca之间存在关联。为了更好地了解社会人口因素在这些关联中的作用，未来的研究是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.