Digit Length Ratio as an Indicator of Fetal Androgen Levels: Relationship to Prostate Volume-Related Men Lower Urinary Tract Symptoms

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-02-19 DOI:10.1111/luts.70009

İsmail Emre Ergin, Abuzer Öztürk, Aydemir Asdemir

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引用次数: 0

Abstract

Objective

This study aimed to investigate the relationship between the 2nd and 4th digit ratios, which are associated with fetal androgen exposure, and prostate volume and testosterone levels, both of which are linked to lower urinary tract symptoms (LUTS).

Methods

Male patients presenting to our urology clinic with increased prostate volume and LUTS were categorized into two groups: those with BPH and those without (non-BPH). For both groups, the right-hand 2D:4D finger ratio, testosterone levels, prostate volume, uroflow parameters, and IPSS scores were recorded.

Results

The 2D:4D ratio, prostate volumes, Qmax, and IPSS scores differed significantly between the BPH and non-BPH groups (p = 0.023, 0.002, 0.000, 0.001). No significant difference was observed in total testosterone levels between the groups (p = 0.381). The 2D:4D ratio was negatively correlated with prostate volume and IPSS (r = −0.389, −0.308) and positively correlated with Qmax (r = 0.301).

Conclusions

Our study demonstrates that the 2D:4D ratio is a straightforward and effective tool for assessing BPH patients, as it correlates with the severity of LUTS symptoms. This non-invasive measure offers potential value in evaluating LUTS, and with age standardization, it could be applied more broadly across age groups. Further large-scale studies are needed to refine its standardization and expand upon current findings.

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手指长度比作为胎儿雄激素水平的指标：与前列腺体积相关的男性下尿路症状的关系

目的本研究旨在探讨与胎儿雄激素暴露相关的第2和第4指比例与前列腺体积和睾丸激素水平之间的关系，这两者都与下尿路症状（LUTS）有关。方法将泌尿外科就诊的前列腺体积增大、LUTS增高的男性患者分为有前列腺增生和无前列腺增生（非前列腺增生）两组。两组均记录右手2D:4D手指比例、睾酮水平、前列腺体积、尿流参数和IPSS评分。结果BPH组与非BPH组的2D:4D比值、前列腺体积、Qmax、IPSS评分差异均有统计学意义（p = 0.023、0.002、0.000、0.001）。两组总睾酮水平差异无统计学意义（p = 0.381）。2D:4D比值与前列腺体积、IPSS呈负相关（r =−0.389、−0.308），与Qmax呈正相关（r = 0.301）。我们的研究表明，2D:4D比值是评估BPH患者的一种简单有效的工具，因为它与LUTS症状的严重程度相关。这种非侵入性措施为评估LUTS提供了潜在的价值，随着年龄的标准化，它可以更广泛地应用于各个年龄组。需要进一步的大规模研究来完善其标准化并扩展目前的研究结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

LUTS: Lower Urinary Tract Symptoms UROLOGY & NEPHROLOGY-

CiteScore

3.00

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： LUTS is designed for the timely communication of peer-reviewed studies which provides new clinical and basic science information to physicians and researchers in the field of neurourology, urodynamics and urogynecology. Contributions are reviewed and selected by a group of distinguished referees from around the world, some of whom constitute the journal''s Editorial Board. The journal covers both basic and clinical research on lower urinary tract dysfunctions (LUTD), such as overactive bladder (OAB), detrusor underactivity, benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), urinary incontinence, pelvic organ prolapse (POP), painful bladder syndrome (PBS), as well as on other relevant conditions. Case reports are published only if new findings are provided. LUTS is an official journal of the Japanese Continence Society, the Korean Continence Society, and the Taiwanese Continence Society. Submission of papers from all countries are welcome. LUTS has been accepted into Science Citation Index Expanded (SCIE) with a 2011 Impact Factor.