Comparison of clomiphene citrate + letrozole add-on versus classical ovarian stimulation protocols in diminished ovarian reserve patients

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-02-19 DOI:10.1111/jog.16245

Mehmet Tunç, Göğşen Önalan

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引用次数: 0

Abstract

Aim

To investigate if there is any benefit of adding clomiphene citrate (CC) + letrozole to controlled ovarian stimulation (COS) cycles on the total gonadotropin dose in POSEIDON group 4 diminished ovarian reserve (DOR) patients.

Methods

A total of 61 DOR patients who underwent 150 COS cycles between 2020 and 2023 in our center were investigated retrospectively. The patients were divided into three main subgroups: group A, group B, and group C. In group A, gonadotropin stimulation started after the completion of 5 days of co-treatment with CC (50 mg twice daily) and letrozole (2.5 mg twice daily). In group B, patients received gonadotropins after completing 5 days of letrozole (2.5 mg twice, daily), and in group C, patients started gonadotropins only.

Results

Mean age was higher in groups A and B. Body mass index, previous parity, and mean AMH levels were similar between the groups. Day 2 antral follicle count was significantly lower in group A (0.90, 1.45 and 1.53; p = 0.017). The need for gonadotropins was lower in group A compared to groups B and C (p = 0.131, and p = 0.029; respectively). Cycle cancellation rates, follicle count on trigger day, number of mature oocytes, number of cleavage stage embryos, and number of blastocyst stage embryos were similar between the groups.

Conclusion

CC + letrozole co-treatment before starting gonadotropin stimulation in POSEIDON group 4 DOR patients might reduce the need for gonadotropins, with similar live birth rates in COS cycles.

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.