Physicochemical patterns of dilute aqueous solutions of biologically active substances: a relationship of self-organization, properties, and bioeffects

Abstract

The results of studies are considered in which the key physicochemical patterns of aqueous solutions of biologically active substances (BAS) of low concentrations prepared by the method of decimal dilutions and maintained under the conditions of natural and lowered levels of external physical fields have been established for the first time and described in terms of the self-organization of dispersed systems based on the study of a complex of experimental methods. A relationship between nonmonotonic coherent concentration dependences of the size, ζ-potential of the dispersed phase (nanoassociates), fluorescence intensity, UV absorption, specific electrical conductivity, surface tension, pH, and found by ecotoxicological tests biological properties of dilute solutions of practically important BAS (drugs, metabolic regulators, pesticides) was revealed using the developed algorithm. It has been shown that the consistency of nonmonotonic changes in the parameters of nanoassociates and properties of the systems in the range of low calculated concentrations makes it possible to predict bioeffects of the dilute BAS systems based on their physicochemical screening. The developed approach, which has predictive capabilities, and the established patterns contribute to the scientific foundation associated with the physicochemical substantiation of the nonmonotonic changes in the properties and elucidation of the mechanisms of the influence of aqueous dilute BAS systems and hypomagnetic conditions on the functioning of living organisms and form a methodological basis for future technologies in medicine, agriculture, protection of aquatic ecosystems and other areas of human activity.