Synthesis of methylated and trifluoromethylated hydroxy thiols based on myrtenal

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-02-20 DOI:10.1007/s11172-024-4470-9

N. O. Ilchenko, D. V. Sudarikov, R. V. Rumyantcev, S. A. Rubtsova, A. V. Kutchin

引用次数: 0

Abstract

A new method was developed for the stereoselective synthesis of methylated and trifluoromethylated thiols based on (1R)-(–)-myrtenal. The CF₃-substituted ketone and CH₃-substituted thioacetate, which are required for the synthesis of the corresponding thiols, were prepared for the first time in 83% and 73% yields, respectively. The yields of CH₃- and CF₃-substituted thiols are 70% (de >99%) and 53% (de >99%) after two steps, respectively.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.