Ya. A. Gur’eva, O. A. Zalevskaya, V. A. Makarov, A. V. Kutchin
{"title":"New heteroleptic palladium complexes with amino acid and bornane ligands: synthesis and antibacterial activity","authors":"Ya. A. Gur’eva, O. A. Zalevskaya, V. A. Makarov, A. V. Kutchin","doi":"10.1007/s11172-024-4468-3","DOIUrl":null,"url":null,"abstract":"<div><p>Novel chiral palladium complexes containing camphor benzylimine and <span>l</span>-amino acids (proline, tyrosine, serine, isoleucine) as ligands were synthesized and characterized by elemental analysis and by NMR and IR spectroscopies. The antibacterial activity of the new and previously synthesized complexes and reference compounds against the bacteria MRSA, <i>S. aureus, P. aeruginosa, E. coli</i>, and <i>M. vaccae</i> was studied. It was found that the introduction of an amino acid ligand does not contribute to the activity of the mononuclear complex compared to the starting binuclear analogue. The binuclear palladacycle obtained from camphor benzylimine showed the highest activity against the pathogenic strains MRSA and <i>M. vaccae</i> (MIC = 8 mg L<sup>−1</sup>), which is comparable with that of the clinical antibiotics used for comparison.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"73 12","pages":"3578 - 3585"},"PeriodicalIF":1.7000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Chemical Bulletin","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11172-024-4468-3","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Novel chiral palladium complexes containing camphor benzylimine and l-amino acids (proline, tyrosine, serine, isoleucine) as ligands were synthesized and characterized by elemental analysis and by NMR and IR spectroscopies. The antibacterial activity of the new and previously synthesized complexes and reference compounds against the bacteria MRSA, S. aureus, P. aeruginosa, E. coli, and M. vaccae was studied. It was found that the introduction of an amino acid ligand does not contribute to the activity of the mononuclear complex compared to the starting binuclear analogue. The binuclear palladacycle obtained from camphor benzylimine showed the highest activity against the pathogenic strains MRSA and M. vaccae (MIC = 8 mg L−1), which is comparable with that of the clinical antibiotics used for comparison.
期刊介绍：
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.
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